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植物源生物黏附剂在创伤敷料和药物传递系统中的应用。

Plant-derived bioadhesives for wound dressing and drug delivery system.

机构信息

School of Biotechnology, National Institute of Technology, Calicut 673601, Kerala, India.

School of Biotechnology, National Institute of Technology, Calicut 673601, Kerala, India.

出版信息

Fitoterapia. 2019 Sep;137:104241. doi: 10.1016/j.fitote.2019.104241. Epub 2019 Jun 12.

Abstract

Synthetic polymers have been widely used in various biomedical applications like drug delivery, wound dressing, etc. They pose a question of bio-compatibility and bio-accumulation, limiting to a minimum class of synthetic polymers to be efficient and versatile. Hence, one cheap and reliant replacement is the use of natural adhesives over the synthetic adhesive polymeric system. The pluripotency of plant could be exploit, making it a perfect candidate for extraction of plant-derived adhesives component for wound dressing and drug delivery system in large-scale production. Current advancement use excipients which influence, the rate of drug release and absorption. Properties like matrix formation and environment responsive gelation can be exploited through these plant-derived components for controlled drug release according to specific therapeutic requirement. This review explores such plant-derived bioactive component: Mucilage and gums, their isolation, and characterization which can be exploited as excipients in the formulation of drug delivery system as well as a wound dressing.

摘要

合成聚合物已广泛应用于药物输送、伤口敷料等各种生物医学领域。它们存在生物相容性和生物积累性的问题,这限制了合成聚合物的最小有效和多功能类别。因此,一种廉价且可靠的替代品是在合成胶态聚合物系统上使用天然胶。植物的多功能性可以被利用,使它成为提取植物源胶黏剂成分用于伤口敷料和药物输送系统的理想候选物。目前的进展利用赋形剂来影响药物的释放和吸收速率。通过这些植物来源的成分,可以利用类似基质形成和环境响应凝胶化的特性,根据特定的治疗需求进行控制药物释放。本综述探讨了此类植物源生物活性成分:黏液和树胶,它们的分离和表征,可作为药物输送系统以及伤口敷料配方中的赋形剂加以利用。

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