Montagnac R, Schillinger F, Milcent T, Cheriot J, Dupoirieux J, Turret M M, Manceaux J C
Service de Néphrologie-Hémodialyse, Centre Hospitalier Général de Troyes.
Nephrologie. 1987;8(5):257-9.
Three capillary dialyzers, with highly permeable membranes, have been compared for their capacity of epuration of blood urea nitrogen, creatinine, phosphorus, uric acid and beta 2 microglobulin, and for their respective protein losses. There were very little differences between the dialyzers for epuration of small uremic molecules, with no benefit due to high permeability membranes in comparison with conventional dialyzers. Protein losses may be important and have to be known. About beta 2 microglobulin, filtered quantities are not correlated to changes in serum levels, suggesting the presence of other mechanisms (adsorption on the membrane and generation during hemodialysis) which influence, together with epuration, perdialytic changes of serum beta 2 microglobulin concentrations.
对三种具有高通透性膜的毛细血管透析器进行了比较，比较它们对血液中尿素氮、肌酐、磷、尿酸和β2微球蛋白的清除能力以及各自的蛋白质损失情况。在清除尿毒症小分子方面，透析器之间差异很小，与传统透析器相比，高通透性膜并无优势。蛋白质损失可能很显著，必须加以了解。关于β2微球蛋白，滤过量与血清水平变化无关，这表明存在其他机制（膜吸附和血液透析过程中生成），这些机制与清除作用一起影响血清β2微球蛋白浓度的透析后变化。
