Challacombe D N, Wheeler E E
Somerset Children's Research Unit, Musgrove Park Hospital, Taunton, Somerset.
Nutr Health. 1987;5(3-4):145-52. doi: 10.1177/026010608700500405.
Children with untreated coeliac disease are characteristically unhappy and after a few days of treatment with a gluten-free diet their mood improves. This improvement in mood can be rapidly reversed by introducing gluten into their diet again which suggests that a humoral agent could be involved in this process. As serotonin is a neurotransmitter in the brain and abnormalities of serotonin metabolism have been reported in coeliac disease, this biogenic amine could be the humoral agent that mediates the changes of mood in coeliac disease. In this review the relationship between the mood changes in coeliac disease and serotonin metabolism will be further examined.
未经治疗的乳糜泻患儿通常情绪不佳，而在采用无麸质饮食治疗几天后，他们的情绪会有所改善。再次在饮食中引入麸质可迅速逆转这种情绪改善的情况，这表明可能有体液因子参与了这一过程。由于血清素是大脑中的一种神经递质，且乳糜泻中已报道有血清素代谢异常，这种生物胺可能就是介导乳糜泻患者情绪变化的体液因子。在这篇综述中，将进一步探讨乳糜泻患者情绪变化与血清素代谢之间的关系。
