Saga University Hospital Medical Engineering Center.
Kyushu University Interdisciplinary Graduate School of Engineering Sciences.
Biocontrol Sci. 2020;25(4):185-191. doi: 10.4265/bio.25.185.
In low-temperature sterilization for the medical field, hydrogen peroxide sterilization is widely used for its safety. However, its low penetrability and residual amount of sterilant are major concerns. Recently, the combination of hydrogen peroxide and peracetic acid has been found to enforce sporicidal effect, with low concentration in hydrogen peroxide. The application of this finding in medical sterilization is still very limited. To elucidate the combination effect, we compare peracetic acid containing hydrogen peroxide gas sterilizer and conventional hydrogen peroxide gas (plasma) sterilizers. The sterilant penetrability was examined in hollow load process challenge devices with inner diameters of 1 and 2 mm and lengths of 1, 2, and 3 m. As a result, peracetic acid containing hydrogen peroxide gas sterilizer demonstrated total inactivation with all diameters and lengths and achieved the highest sterilant penetrability in this study. The amount of residual sterilant on the surface of the sterilized object was 4.2 μg/cm, which corresponds to half amount of those of conventional hydrogen peroxide gas sterilizers. These results suggest that the addition of peracetic acid to hydrogen peroxide gas sterilizer can enhance sterilization efficiency and safety.
在医疗领域的低温灭菌中，过氧化氢灭菌因其安全性而被广泛应用。然而，其低穿透力和残留消毒剂问题仍是主要关注点。最近，发现过氧化氢与过氧乙酸的结合可以增强杀菌效果，且过氧化氢的浓度较低。这一发现应用于医疗灭菌的情况仍然非常有限。为了阐明联合作用，我们比较了含有过氧乙酸的过氧化氢气体灭菌器和传统的过氧化氢气体（等离子体）灭菌器。通过内径为 1 和 2 毫米、长度为 1、2 和 3 米的空心负载过程挑战装置来检查消毒剂的穿透力。结果表明，含有过氧乙酸的过氧化氢气体灭菌器在所有直径和长度下均实现了完全灭活，并在本研究中达到了最高的消毒剂穿透力。灭菌物体表面的残留消毒剂量为 4.2μg/cm，相当于传统过氧化氢气体灭菌器的一半。这些结果表明，在过氧化氢气体灭菌器中添加过氧乙酸可以提高灭菌效率和安全性。
