Singh Vibha, Gupta Abhaya, Verma Umesh Pratap, Mishra Tripti, Pal Mahesh
Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George's Medical University, Lucknow, Uttar Pradesh, India.
Department of Periodontology, Faculty of Dental Sciences, King George's Medical College, Lucknow, Uttar Pradesh, India.
Ayu. 2019 Jul-Sep;40(3):152-158. doi: 10.4103/ayu.AYU_68_18. Epub 2020 Aug 8.
Gingivitis is a relatively innocuous and reversible inflammation of gingiva. If left untreated, it might progress involving the deeper supporting periodontal tissues of the tooth with consequent mobility and tooth loss. Compelling literature has suggested the role of local antibacterial and anti‑inflammatory agents as an adjunct to scaling and root planing (gold standard) for treating periodontal diseases. Various herbs such as ( A. Juss), ( (L.) P.J.H. Hurter & Mabb.) and turmeric (a L.) have been used for gingivitis since ancient times. L. () is one such herb known for its remarkable anti‑inflammatory, antioxidant and antimicrobial properties and thus has been utilized in the present study.
The aim of the study was to explore the clinical efficacy of different ethanolic solutions of in moderate‑to‑severe gingivitis patients.
It is a split‑mouth clinical study with 24 patients of moderate‑to‑severe gingivitis from the age group of 25-45 years. Recruited individuals were divided in to group I, group II and group III (scaling and root planning i.e., control) and group I, group II and group III (experimental). Three doses of solution 1 (1:3), solution 2 (1:1) and solution 3 (3:1) were administered to the experimental groups for 3 consecutive days. The clinical parameters, i.e., gingival index (GI) and plaque index (PI) were recorded at baseline, 14 days and 28 days in all the individuals. ANOVA test was used in the study for statistical analysis.
Intergroup comparison in terms of GI showed statistically significant difference at 14 and 28 day from baseline between II at only 28 day between II & II and insignificant difference between III & III at all time intervals from baseline. On intragroup comparison, statistically significant reduction in GI in all groups from baseline till 28 days was found, but among experimental groups best result was seen in group III ( < 0.001; F value 153.75). As far as PI is concerned, intergroup comparison between different groups displayed statistically significant difference from baseline to 14 and 28 day between all groups i.e I& I, II& II and III& III. On intragroup comparison, statistically significant reduction in PI in all control groups i.e I II & III was found, but among experimental groups only group III provided statistically significant reduction ( < 0.001, F value 30.40).
The results of this study indicate that, the ethanolic extract of is effective in the treatment of moderate to severe gingivitis.
牙龈炎是牙龈相对无害且可逆的炎症。若不治疗，它可能会发展至累及牙齿更深层的牙周支持组织，进而导致牙齿松动和脱落。有确凿的文献表明，局部抗菌和抗炎药物可作为洁治和根面平整（金标准）治疗牙周疾病的辅助手段。自古以来，各种草药如（某种植物A. Juss）、（另一种植物（L.）P.J.H. Hurter & Mabb.）和姜黄（一种植物a L.）就被用于治疗牙龈炎。[某种植物名] L.（括号内为具体植物名）就是这样一种以其显著的抗炎、抗氧化和抗菌特性而闻名的草药，因此在本研究中被加以利用。
本研究的目的是探讨[某种植物名]不同乙醇溶液对中重度牙龈炎患者的临床疗效。
这是一项口内对照临床研究，纳入了24名年龄在25 - 45岁的中重度牙龈炎患者。招募的个体被分为第一组、第二组和第三组（洁治和根面平整即对照组）以及第一组、第二组和第三组（试验组）。试验组连续3天给予三种剂量的溶液1（1:3）、溶液2（1:1）和溶液3（3:1）。在所有个体的基线、第14天和第28天记录临床参数，即牙龈指数（GI）和菌斑指数（PI）。本研究采用方差分析进行统计分析。
就GI而言，组间比较显示，第二组与基线相比在第14天和第28天有统计学显著差异，第二组与第三组仅在第28天有差异，而第三组与第三组在所有时间间隔与基线相比均无显著差异。组内比较发现，所有组从基线到第28天GI均有统计学显著降低，但试验组中第三组效果最佳（P < 0.001；F值153.75）。就PI而言，不同组间的组间比较显示，从基线到第14天和第28天所有组（即第一组与第一组、第二组与第二组、第三组与第三组）均有统计学显著差异。组内比较发现，所有对照组（即第一组、第二组和第三组）PI均有统计学显著降低，但试验组中只有第三组有统计学显著降低（P < 0.001，F值30.40）。
本研究结果表明，[某种植物名]的乙醇提取物对治疗中重度牙龈炎有效。
