Mavligit G M
Department of Clinical Immunology and Biologic Therapy, M.D. Anderson Hospital and Tumor Institute, Houston, Texas 77030.
Pharmacotherapy. 1987;7(6 Pt 2):120S-124S. doi: 10.1002/j.1875-9114.1987.tb03536.x.
Suppressor T lymphocytes play a major regulatory role in the function of the immune system. Since the discovery of histamine (H2) receptors on the surface of these immune cells, studies have demonstrated that cimetidine diminishes the effect of suppressor T cells in both cellular- and humoral-mediated (antibody) immune reactions. Preliminary clinical results demonstrate that cimetidine has a beneficial effect on a variety of immune functions. An antineoplastic effect among tumor-bearing animals has also been found, suggesting the drug may be effective against certain human cancers, probably as an immune potentiator. Cimetidine has been used in the treatment of human cancer in combination with interferon or coumarin and as a single agent. Modest tumor response rates have been observed. The finding that cimetidine accelerates healing of herpesvirus infections is intriguing. These encouraging, albeit preliminary, results emphasize the need for additional studies on the drug's antiviral properties.
抑制性T淋巴细胞在免疫系统功能中发挥着主要调节作用。自从在这些免疫细胞表面发现组胺（H2）受体以来，研究表明西咪替丁在细胞介导和体液介导（抗体）的免疫反应中都会减弱抑制性T细胞的作用。初步临床结果表明，西咪替丁对多种免疫功能具有有益作用。在荷瘤动物中也发现了抗肿瘤作用，这表明该药物可能对某些人类癌症有效，可能是作为一种免疫增强剂。西咪替丁已与干扰素或香豆素联合用于治疗人类癌症，也可单独使用。已观察到适度的肿瘤反应率。西咪替丁可加速疱疹病毒感染愈合这一发现很有趣。这些令人鼓舞的结果尽管只是初步的，但强调了对该药物抗病毒特性进行更多研究的必要性。
