Nsaful Josephine, Vanderpuye Verna, Scott Aba Anoa, Dedey Florence, Oppong Samuel A, Appiah-Danquah Rita, Damale Nelson, Fenu Benjamin, Wordui Theodore, Yarney Joel, Clegg-Lamptey Joe Nat
University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle-Bu, Accra, GA-379-5258, Ghana.
Department of Surgery, Korle Bu Teaching Hospital, Accra, GA-379-5258, Ghana.
Ecancermedicalscience. 2020 Nov 10;14:1140. doi: 10.3332/ecancer.2020.1140. eCollection 2020.
Breast cancer is the commonest female cancer worldwide and the most common malignancy during pregnancy. The current management of breast cancer is based on patient and tumour characteristics, preferences and disease stage. In pregnancy-associated breast cancer, the gestational age influences treatment options. Sequencing of therapies is guided by safe imaging options, timing of delivery and prognosis. Systemic therapy options in the neoadjuvant, adjuvant and palliative settings are limited due to safety concerns of the unborn foetus. In resource-constrained regions, the application of safe options may be challenging. This paper reports four of such cases managed in Ghana using a multidisciplinary approach and local resource-appropriate evidence-based practices. Maternal and foetal outcomes were acceptable with none resulting in termination of pregnancy.
乳腺癌是全球最常见的女性癌症，也是孕期最常见的恶性肿瘤。目前乳腺癌的治疗基于患者和肿瘤特征、偏好以及疾病分期。在妊娠相关乳腺癌中，孕周会影响治疗选择。治疗顺序由安全的影像学检查、分娩时机和预后决定。由于未出生胎儿的安全问题，新辅助、辅助和姑息治疗中的全身治疗选择有限。在资源有限的地区，应用安全的治疗方案可能具有挑战性。本文报告了在加纳采用多学科方法和适合当地资源的循证实践管理的4例此类病例。母婴结局良好，均未导致终止妊娠。
