Xinjiang Mental Health Center and Urumqi Fourth People's Hospital, Urumqi 830002, China.
Dis Markers. 2020 Nov 17;2020:8850859. doi: 10.1155/2020/8850859. eCollection 2020.
The underlying mechanisms of alcohol use disorder (AUD) are regarded to be strongly associated with genetic factors. Although great efforts have been made to identify the association of rs4680 polymorphism in the catechol-o-methyltransferase gene and risk to AUD, the outcomes were still inconsistent. This study is aimed at exploring the association of rs4680 polymorphism and AUD by using a meta-analysis approach.
Literature searching was undertaken across PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases. We set the search period before February 20, 2020. We used the Review Manager 5.3 (RevMan 5.3) software to estimate the effect sizes in five genetic models.
In total, eighteen case-control studies and two cohort studies were included in this study. The merged results of overall population indicated there was no significant association between rs4680 polymorphism and AUD: V vs. M, OR = 1.02, 95% CI 0.93-1.12, = 0.70; VV vs. MM, OR = 0.99, 95% CI 0.79-1.23, = 0.92; VM vs. MM, OR = 0.91, 95% CI 0.81-1.03, = 0.15; VV+VM vs. MM, OR = 0.95, 95% CI 0.80-1.13, = 0.65; VV vs. VM+MM, OR = 1.04, 95% CI 0.91-1.18, = 0.57. Subgroup analysis by gender suggested rs4680 polymorphism was marginally associated with an elevated risk to AUD among males (VM vs. MM, OR = 0.81, 95% CI 0.67-0.98, = 0.03). However, subgroup analysis by race and diagnosis did not support any significant association.
The present study suggests that rs4680 polymorphism has no association with AUD in the overall population, but it has a weak association with AUD in males. Carriers of VM genotype in males appear to have an increased risk to AUD.
酒精使用障碍（AUD）的潜在机制被认为与遗传因素密切相关。尽管已经做出了巨大努力来确定儿茶酚-O-甲基转移酶基因 rs4680 多态性与 AUD 风险的关联，但结果仍然不一致。本研究旨在通过荟萃分析方法探讨 rs4680 多态性与 AUD 的关联。
通过 PubMed、Embase、Web of Science、中国知网（CNKI）和万方数据库对文献进行检索。我们设定了搜索截止日期为 2020 年 2 月 20 日之前。我们使用 Review Manager 5.3（RevMan 5.3）软件在五种遗传模型中估计效应大小。
共有 18 项病例对照研究和 2 项队列研究纳入本研究。总体人群的合并结果表明，rs4680 多态性与 AUD 之间无显著关联：V 对 M，OR = 1.02，95%CI 0.93-1.12， = 0.70；VV 对 MM，OR = 0.99，95%CI 0.79-1.23， = 0.92；VM 对 MM，OR = 0.91，95%CI 0.81-1.03， = 0.15；VV+VM 对 MM，OR = 0.95，95%CI 0.80-1.13， = 0.65；VV 对 VM+MM，OR = 1.04，95%CI 0.91-1.18， = 0.57。按性别进行的亚组分析表明，rs4680 多态性与男性 AUD 风险升高呈边缘相关（VM 对 MM，OR = 0.81，95%CI 0.67-0.98， = 0.03）。然而，按种族和诊断进行的亚组分析不支持任何显著关联。
本研究表明，rs4680 多态性与总体人群中的 AUD 无关，但与男性 AUD 有较弱的关联。男性携带 VM 基因型的个体似乎 AUD 风险增加。
