Litvinova Karina, Chernysheva Maria, Stegemann Berthold, Leyva Francisco
Aston Medical School, Aston University, Aston Triangle, B4 7ET, Birmingham, UK.
Leibniz Institute of Photonic Technology, Albert Einstein str 9, 07745, Jena, Germany.
Biomed Opt Express. 2020 Oct 9;11(11):6271-6280. doi: 10.1364/BOE.400504. eCollection 2020 Nov 1.
Wound healing and other surgical technologies traditionally solved by suturing and stapling have recently been enhanced by the application of laser tissue welding. The usage of high energy laser radiation to anastomose tissues eliminates a foreign body reaction, reduces scar formation, and allows for the creation of watertight closure. In the current work, we show that an ultrafast pulsed fibre laser beam with 183 J·cm energy fluence at 1550 nm provides successful welding of dissected chicken heart walls with the tensile strength of 1.03±0.12 kg·cm equal to that of native tissue. The welding process was monitored employing fluorescence spectroscopy that detects the biochemical composition of tissues. We believe that fluorescence spectroscopy guided laser tissue welding is a promising approach for decreasing wound healing times and the avoiding risks of postoperative complications.
传统上通过缝合和钉合解决的伤口愈合及其他外科技术，近来因激光组织焊接技术的应用而得到改进。使用高能激光辐射来吻合组织可消除异物反应，减少疤痕形成，并实现水密性闭合。在当前的研究中，我们表明，波长为1550 nm、能量通量为183 J·cm的超快脉冲光纤激光束能够成功焊接解剖后的鸡心壁，其抗拉强度为1.03±0.12 kg·cm，与天然组织相当。采用荧光光谱法监测焊接过程，该方法可检测组织的生化成分。我们认为，荧光光谱引导的激光组织焊接是一种很有前景的方法，可减少伤口愈合时间并避免术后并发症风险。
