Alsaqabi Yasir S, Rabbani Unaib
Family Medicine Academy, Qassim Health Cluster, Buraidah, SAU.
Cureus. 2020 Dec 2;12(12):e11853. doi: 10.7759/cureus.11853.
Background Chronic diseases require long-term medication and adherence to medication is important for the control of disease as well as prevention of complications. Non-compliance may lead to worsening of the disease, which may affect patients' quality of life. This study aimed to assess the level of medication adherence and its association with quality of life (QOL) among hypertensive patients in Buraidah, Saudi Arabia. Methods A cross-sectional study was carried out in which 299 hypertensive patients were recruited from the randomly selected primary health care centers. Medication adherence was assessed by Hill-Bone Medication Adherence Scale, and quality of life was assessed by the World Health Organization's Quality of Life (WHOQOL)-BREF. Multivariate linear regression was used to assess the association of medication adherence with quality of life. Data was analyzed using SPSS version 21.0 (IBM Inc., Armonk, USA). Results The prevalence of poor adherence was found to be 38.8%. We did not find a significant association of medication adherence with any of the four (physical, psychological, social relationship, and environmental) domains of WHOQOL-BREF. However, poor medication adherence was associated with poor perceived overall QOL adjusted β=-0.012 (95% confidence interval [CI]: -0.021 to -0.002; p=0.018) and health adjusted β=-0.013 (95% CI: -0.025 to -0.002; p<0.018). Conclusion We found a high prevalence of non-adherence among hypertensive patients. This calls for developing interventions to improve compliance with medications to prevent complications of hypertension. Our study could not find a significant association of medication adherence with any of the domains of QOL, while poor adherence was associated with lower overall perceived QOL and health. Nonetheless, worsening of disease due to non-adherence may affect the QOL of patients. We recommend large scale prospective studies to explore the relationship between medication adherence and QOL.
背景 慢性病需要长期用药，坚持用药对于控制疾病以及预防并发症至关重要。不依从可能导致疾病恶化，进而影响患者的生活质量。本研究旨在评估沙特阿拉伯布赖代高血压患者的用药依从水平及其与生活质量（QOL）的关联。方法 开展了一项横断面研究，从随机选取的初级卫生保健中心招募了299名高血压患者。采用希尔-博恩用药依从性量表评估用药依从性，采用世界卫生组织生活质量量表简表（WHOQOL-BREF）评估生活质量。使用多元线性回归评估用药依从性与生活质量的关联。数据采用SPSS 21.0版（美国国际商业机器公司，纽约州阿蒙克）进行分析。结果 发现依从性差的患病率为38.8%。我们未发现用药依从性与WHOQOL-BREF的四个领域（生理、心理、社会关系和环境）中的任何一个存在显著关联。然而，用药依从性差与总体生活质量感知较差相关（调整后的β=-0.012，95%置信区间[CI]：-0.021至-0.002；p=0.018），与健康状况相关（调整后的β=-0.013，95%CI：-0.025至-0.002；p<0.018）。结论 我们发现高血压患者中不依从的患病率较高。这就需要制定干预措施以提高用药依从性，预防高血压并发症。我们的研究未发现用药依从性与生活质量的任何领域存在显著关联，而依从性差与总体生活质量感知较低和健康状况较差相关。尽管如此，不依从导致的疾病恶化可能会影响患者的生活质量。我们建议开展大规模前瞻性研究，以探索用药依从性与生活质量之间的关系。
