Department of Anesthesiology, Weill Cornell Medicine, 525 East 68th Street, Box 124, New York, NY 10065, USA.
Weill Cornell Medical College, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
J Comp Eff Res. 2022 Jun;11(9):689-698. doi: 10.2217/cer-2022-0027. Epub 2022 May 5.
To provide a comprehensive understanding of the varying effects of SARS-CoV-2 infection based on sex. A PubMed search of 470 primary articles was performed, with inclusion based on relevance (sex differences discussed in the target COVID population) and redundancy. PubMed was queried based on title for the keywords "SEX" and "COVID" or "SARS" between 2020 and 2022. For COVID-19, males have increased risk for infectivity and intensive care unit admission and worse overall outcomes compared with females. Genetic predispositions, sex hormones, immune system responses and non-biological causes all contribute to the disparity in COVID-19 responses between the sexes. COVID-19 sex-related determinants of morbidity and mortality remain unclear. Male sex is a risk factor for several overall worse outcomes related to COVID-19. Investigating the sex impact of COVID-19 is an important part of understanding the behavior of the disease. Future work is needed to further explore these relationships and optimize the management of COVID-19 patients based on sex.
为了全面了解 SARS-CoV-2 感染基于性别的不同影响。我们对 470 篇原始文章进行了 PubMed 检索，纳入标准基于相关性（目标 COVID 人群中讨论的性别差异）和冗余性。在 2020 年至 2022 年期间，我们基于标题在 PubMed 上使用了“SEX”和“COVID”或“SARS”这两个关键词进行了查询。与女性相比，男性在感染性和入住重症监护病房以及整体预后方面的风险更高。遗传易感性、性激素、免疫系统反应和非生物学原因都导致了 COVID-19 反应中性别差异的存在。COVID-19 发病率和死亡率的性别相关决定因素仍不清楚。男性是与 COVID-19 相关的几种整体预后较差的危险因素。研究 COVID-19 的性别影响是了解疾病行为的重要组成部分。需要进一步的研究来进一步探索这些关系，并根据性别优化 COVID-19 患者的管理。
