Gambardella Alessio, Licata Gaetano, Calabrese Giulia, De Rosa Alina, Pagliuca Francesca, Alfano Roberto, Argenziano Giuseppe
Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Division of Pathology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Psoriasis (Auckl). 2020 Nov 27;10:57-60. doi: 10.2147/PTT.S284701. eCollection 2020.
The use of biological therapy is now common practice in the treatment of immune-mediated inflammatory diseases (IMID). Currently, there are no guidelines related to the management of cytomegalovirus (CMV) infections or reactivation during therapy with biological agents. Furthermore, there is a lack of guidance on the management of asymptomatic patients with persistent positive immunoglobulin (Ig)M anti-CMV after an extended period and who have to undergo therapy with biological agents. We report the case of a patient in this situation for whom treatment with biological drugs for psoriasis was indicated. A good clinical response was obtained with secukinumab and maintained during 6 months of follow-up. No infectious disease or reactivation of CMV infection occurred. We suggest some possible guidelines for the management of such cases.
生物疗法目前在免疫介导的炎症性疾病（IMID）治疗中已普遍应用。目前，尚无关于生物制剂治疗期间巨细胞病毒（CMV）感染或再激活管理的指南。此外，对于长期无症状但免疫球蛋白（Ig）M抗CMV持续阳性且必须接受生物制剂治疗的患者，缺乏管理指导。我们报告了一名处于这种情况且因银屑病而有使用生物药物指征的患者病例。使用司库奇尤单抗获得了良好的临床反应，并在6个月的随访中得以维持。未发生传染病或CMV感染再激活。我们为此类病例的管理提出了一些可能的指南。
