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用于合成电中性和带电荷的抗病毒及抗癌前体核苷酸的H-膦酸酯化学

H-Phosphonate Chemistry in the Synthesis of Electrically Neutral and Charged Antiviral and Anticancer Pronucleotides.

作者信息

Kraszewski Adam, Sobkowski Michal, Stawinski Jacek

机构信息

Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.

出版信息

Front Chem. 2020 Nov 13;8:595738. doi: 10.3389/fchem.2020.595738. eCollection 2020.

DOI:10.3389/fchem.2020.595738
PMID:33282839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7691650/
Abstract

In this review a short account of our work on the synthesis and biological activity of electrically neutral and charged anti-HIV and anticancer pronucleotides, presented on the background of the contemporary research in this area, is given.

摘要

在本综述中，我们介绍了在当代该领域研究背景下，关于电中性和带电荷的抗HIV及抗癌前体核苷酸的合成与生物活性的工作简述。

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