双（2,2,2-三氟乙基）膦酸酯作为合成H-膦酸酯的便捷前体。
Bis(2,2,2 trifluoroethyl) Phosphonate as a Convenient Precursor for the Synthesis of H-Phosphonates.
作者信息
Pohl Jean-Marie, Stöhr Fabian, Kramer Tim, Becker Jonathan, Göttlich Richard
机构信息
Institute for Organic Chemistry, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Institute for Inorganic and Analytical Chemistry, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
出版信息
Molecules. 2024 May 21;29(11):2432. doi: 10.3390/molecules29112432.
A microwave-assisted synthesis of dialkyl and cyclic H-phosphonates via bis(2,2,2 trifluoroethyl) phosphonate (BTFEP) is described. This method enables the synthesis of various cyclic H-phosphonates and hetero-substituted dialkyl H-phosphonates by simple alcoholysis under non-inert and additive-free conditions. Short reaction times and the requirement for only stoichiometric amounts of alcohol render this method attractive for synthetic applications.
描述了一种通过双（2,2,2-三氟乙基）膦酸酯（BTFEP）微波辅助合成二烷基和环状H-膦酸酯的方法。该方法能够在非惰性和无添加剂条件下通过简单的醇解反应合成各种环状H-膦酸酯和杂取代二烷基H-膦酸酯。短反应时间以及仅需化学计量的醇使得该方法在合成应用中具有吸引力。
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