Zhu Sheng, Huang Yaxiong, Tang Wei, Nussler Andreas K, Zheng Fang
Department of Trauma and Reconstructive Surgery, BG Trauma Center Tuebingen, Siegfried Weller Institute for Trauma Research, Eberhard Karls University Tuebingen, Tuebingen, Germany.
The First Hospital of Changsha, Changsha, China.
Front Med (Lausanne). 2020 Nov 12;7:575439. doi: 10.3389/fmed.2020.575439. eCollection 2020.
Severe acute respiratory syndrome (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), has become a global pandemic in the past months. An overall defined treatment has not yet been established. Therefore, it is important to summarize and report treatment experiences and identify patient groups that have a significantly higher risk of an adverse clinical outcome. Two hundred thirty-nine COVID-19 patients were recruited from January 25 to February 15, 2020. Demographic, clinical, laboratory, treatment management, and outcome data obtained from patients' medical records were evaluated. Patients who recovered from PCR positive to negative within 2 weeks had significantly lower erythrocyte sedimentation rate (ESR) and higher C-reactive protein (CRP) levels than those recovered post 2 weeks. During antiviral treatment, COVID-19 patients with older age, comorbidities, and corticosteroid treatment required a significantly longer time to turn from PCR positive to negative COVID-19 result. PCR tests are of great importance to evaluate the recovery of COVID-19-positive patients, and ESR could be an indirect indicator to monitor SARS-COV-2 activity. Furthermore, our data suggest that older age, the existence of comorbidities, and corticosteroid treatment of COVID-19 patients during antiviral treatment could prolong the duration of conversion from SARS-COV-2 positive to negative.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的严重急性呼吸综合征（COVID-19）在过去几个月已成为全球大流行疾病。目前尚未确立全面明确的治疗方法。因此，总结和报告治疗经验并确定临床不良结局风险显著更高的患者群体非常重要。2020年1月25日至2月15日招募了239例COVID-19患者。对从患者病历中获取的人口统计学、临床、实验室、治疗管理和结局数据进行了评估。在2周内从PCR阳性转为阴性的患者，其红细胞沉降率（ESR）显著低于2周后康复的患者，而C反应蛋白（CRP）水平则更高。在抗病毒治疗期间，年龄较大、患有合并症且接受皮质类固醇治疗的COVID-19患者从PCR阳性转为COVID-19阴性结果所需的时间显著更长。PCR检测对于评估COVID-19阳性患者的康复情况非常重要，ESR可能是监测SARS-CoV-2活性的间接指标。此外，我们的数据表明，COVID-19患者在抗病毒治疗期间年龄较大、存在合并症以及接受皮质类固醇治疗可能会延长从SARS-CoV-2阳性转为阴性的时间。
