Hou Hong, Zhou Bing, Wang Jiawei, Zhao Dengyang, Sun Duhao, Chen Xiaoyun, Han Ying, Yan Chaoguo, Shi Yaocheng, Zhu Shaoqun
School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225009, China.
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212005, China.
Org Lett. 2021 Apr 16;23(8):2981-2987. doi: 10.1021/acs.orglett.1c00626. Epub 2021 Mar 30.
Described herein is a stereo- and regioselective -hydrophosphorylation reaction of the internal alkyne of 1,3-enynes that accesses various 1,3-dienes in good isolated yields. The visible-light irradiation of NiCl(PPh) allows the generation of highly reactive nickel(II)-phosphorus species that subsequently migrate into the internal alkyne of the 1,3-enynes and protonate the resulting vinyl nickel species, leading to various phosphinoyl 1,3-butadienes under mild reaction conditions.
本文描述了一种1,3-烯炔内炔的立体和区域选择性氢膦酰化反应，该反应能以良好的分离产率得到各种1,3-二烯。NiCl(PPh)的可见光照射能产生高活性的镍（II）-磷物种，该物种随后迁移到1,3-烯炔的内炔中，并使生成的乙烯基镍物种质子化，从而在温和的反应条件下生成各种膦酰基1,3-丁二烯。
