通过串联自由基加成和环化反应实现二烯、烯炔及相关化合物的双官能化。

Jiangsu Key Laboratory for the Chemistry of Low-Dimensional Materials, Huaiyin Normal University, Huai'an 223300, China.

College of Biological Science and Technology, Beijing Forestry University, 35 Qinghua East Road, Beijing 100083, China.

Molecules. 2023 Jan 23;28(3):1145. doi: 10.3390/molecules28031145.

Radical reactions are powerful in creating carbon-carbon and carbon-heteroatom bonds. Designing one-pot radical reactions with cascade transformations to assemble the cyclic skeletons with two new functional groups is both synthetically and operationally efficient. Summarized in this paper is the recent development of reactions involving radical addition and cyclization of dienes, diynes, enynes, as well as arene-bridged and arene-terminated compounds for the preparation of difunctionalization cyclic compounds. Reactions carried out with radical initiators, transition metal-catalysis, photoredox, and electrochemical conditions are included.

自由基反应在构建碳-碳键和碳-杂原子键方面具有强大的能力。设计一锅法自由基反应，通过级联转化来组装具有两个新官能团的环状骨架，在合成和操作上都具有高效率。本文总结了涉及二烯、二炔、烯炔以及芳基桥连和芳基末端化合物的自由基加成和环化反应，用于制备双官能化环状化合物的最新进展。所涉及的反应包括自由基引发剂、过渡金属催化、光氧化还原和电化学条件。