Assistant Professor, Department of Microbiology, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, India.
Consultant Neonatologist, Department of Neonatology, National Institute of Medical and Sciences Medical College, Jaipur, India.
Trop Doct. 2021 Jan;51(1):44-48. doi: 10.1177/0049475520977043. Epub 2020 Dec 6.
Bloodstream infection remains one of the most important causes of morbidity and mortality globally, specifically among intensive care unit patients. This prospective observational study included 887 blood culture samples collected cases admitted to intensive care unit suspected of having sepsis. Samples were cultured and evaluated for antimicrobial susceptibility patterns: 202 (22.78%) blood cultures were positive and yielded microbial growth with 132 (14.88%) having mono-microbial growth. Gram-negative bacteria accounted for 45.2% cases, with being the most common; Gram positives accounted for 43.9% with being most common and 10.9% were fungal isolates. Gram-negative isolates were sensitive to colistin and tigecycline and 77.3% of isolates were extended spectrum beta-lactamase (ESBL) producers. Gram-positive isolates were sensitive to tigecycline, linezolid, vancomycin and teicoplanin with 97.5% being methicillin-resistant (MRSA). Most of the blood culture isolates from critically ill patients in intensive care unit were multidrug-resistant, ESBL producers and MRSA which raises a serious concern about the development of serious antibiotic resistance.
血流感染仍然是全球发病率和死亡率的重要原因之一，特别是在重症监护病房的患者中。这项前瞻性观察研究纳入了 887 例疑似败血症收入重症监护病房的患者的血培养样本。对样本进行培养和评估抗菌药物敏感性模式：202（22.78%）份血培养呈阳性，有微生物生长，其中 132（14.88%）份为单一微生物生长。革兰氏阴性菌占 45.2%，其中 最为常见；革兰氏阳性菌占 43.9%，其中 最为常见，10.9%为真菌分离株。革兰氏阴性分离株对黏菌素和替加环素敏感，77.3%的分离株为产超广谱β-内酰胺酶（ESBL）。革兰氏阳性分离株对替加环素、利奈唑胺、万古霉素和替考拉宁敏感，其中 97.5%为耐甲氧西林金黄色葡萄球菌（MRSA）。重症监护病房重症患者的大多数血培养分离株为多重耐药、产 ESBL 和 MRSA，这引起了对严重抗生素耐药性发展的严重关注。
