Cardiovascular Diabetology Research Group, Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Division of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, Bayreuth, Germany.
Diabetes Obes Metab. 2021 Jul;23(7):1681-1684. doi: 10.1111/dom.14287. Epub 2021 Jan 5.
To investigate differences in heart rate variability (HRV) during oral glucose tolerance tests (OGTTs) in response to the rate of change in glucose and to different glycaemic ranges in individuals with type 1 diabetes. This was a single-centre, prospective, secondary outcome analysis in 17 individuals with type 1 diabetes (glycated haemoglobin 53 ± 6.3 mmol/L), who underwent two OGTTs (after 12 and 36 hours of fasting) investigating differences in HRV in response to rapid glucose increases/decreases and different glycaemic ranges during OGTT. Based on the rate of change in glucose level, the variables heart rate (P < 0.001), square root of the mean standard difference of successive R-R intervals (P = 0.002), percentage of pairs of R-R intervals with >50 ms difference (P < 0.001) and corrected QT interval (P = 0.04) were significantly altered, with HRV particularly reduced during episodes of rapid glucose rises. Glycaemic ranges during OGTT had no impact on HRV (P < 0.05). Individuals with type 1 diabetes showed no changes in HRV in response to different glycaemic ranges. HRV was dependent on the rate of change in glucose, especially rapid increases in glucose level.
研究 1 型糖尿病个体在口服葡萄糖耐量试验（OGTT）中对葡萄糖变化率和不同血糖范围的心率变异性（HRV）差异。这是一项单中心、前瞻性、次要结局分析，纳入 17 名 1 型糖尿病患者（糖化血红蛋白 53 ± 6.3 mmol/L），他们接受了两次 OGTT（禁食 12 小时和 36 小时后），以研究 HRV 在 OGTT 期间对快速葡萄糖增加/减少和不同血糖范围的反应差异。根据血糖水平的变化率，心率（P < 0.001）、连续 R-R 间期均方根标准差（P = 0.002）、>50ms 差异的 R-R 间期对百分比（P < 0.001）和校正 QT 间期（P = 0.04）等变量发生显著变化，HRV 在快速葡萄糖升高期间特别降低。OGTT 期间的血糖范围对 HRV 没有影响（P < 0.05）。1 型糖尿病患者对不同血糖范围的 HRV 没有变化。HRV 取决于血糖变化率，特别是血糖水平的快速升高。
