Eckstein Max Lennart, Brockfeld Antonia, Haupt Sandra, Schierbauer Janis Ramon, Zimmer Rebecca Tanja, Wachsmuth Nadine Bianca, Zunner Beate Elisabeth Maria, Zimmermann Paul, Erlmann Maximilian, Obermayer-Pietsch Barbara, Aberer Felix, Moser Othmar
Division of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany.
Endocrinology Lab Platform, Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
Biology (Basel). 2022 Feb 21;11(2):338. doi: 10.3390/biology11020338.
It is unknown how different types of carbohydrates alter the cardio-autonomic system in healthy individuals. Therefore, the aim of this study was to investigate how heart-rate variability changes to single dose ingestion of glucose, fructose, glucose and fructose, and an artificial sweetener (sucralose).
In a double-blind randomized crossover placebo-controlled setting, 15 participants received all study-specific substances in liquid form. During each 2-h visit, venous blood glucose was measured in a 5-min interval while heart-rate variability was measured continuously via Holter-electrocardiograph.
Ingestion of different types of carbohydrates and sucralose showed significant differences for heart rate ( < 0.001), SDNN ( < 0.008), RMSSD ( < 0.001), pNN50 ( < 0.001) and blood pressure ( < 0.001). Different glucose levels significantly altered parameters of heart-rate variability and blood pressure (all < 0.001), while the rate of change in blood glucose led to changes in heart rate variability, but not in heart rate ( = 0.25) or blood pressure ( = 0.99).
Ingestion of different types of carbohydrates lead to reductions in heart-rate variability compared to a placebo. Blood glucose values above or below 70-90 mg/dL decreased heart rate variability while this was also seen for rapid glucose changes, yet not as pronounced. Healthy individuals should be conscious about carbohydrate intake while maintaining blood glucose levels between 70-90 mg/dL.
尚不清楚不同类型的碳水化合物如何改变健康个体的心脏自主神经系统。因此，本研究的目的是调查单次摄入葡萄糖、果糖、葡萄糖和果糖混合物以及人工甜味剂（三氯蔗糖）后心率变异性如何变化。
在双盲随机交叉安慰剂对照试验中，15名参与者以液体形式接受所有特定研究物质。在每次2小时的访视期间，每隔5分钟测量静脉血糖，同时通过动态心电图仪连续测量心率变异性。
摄入不同类型的碳水化合物和三氯蔗糖后，心率（<0.001）、标准差（SDNN，<0.008）、平方根连续差值（RMSSD，<0.001）、相邻RR间期差值的均方根（pNN50，<0.001）和血压（<0.001）均有显著差异。不同的血糖水平显著改变了心率变异性和血压参数（均<0.001），而血糖变化率导致心率变异性改变，但心率（=0.25）或血压（=0.99）未改变。
与安慰剂相比，摄入不同类型的碳水化合物会导致心率变异性降低。血糖值高于或低于70 - 90mg/dL会降低心率变异性，快速的血糖变化也会出现这种情况，但不那么明显。健康个体在维持血糖水平在70 - 90mg/dL之间时应注意碳水化合物的摄入量。
