NKT 细胞和可溶性 MIC-A 在霍奇金淋巴瘤中的临床意义。
Clinical relevance of NKT cells and soluble MIC-A in Hodgkin lymphoma.
机构信息
Hematology Department, UMAE Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Unidad de Investigación de Medicina Traslacional en Enfermedades Hemato-Oncologicas, UMAE Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
出版信息
Leuk Lymphoma. 2021 Apr;62(4):801-809. doi: 10.1080/10428194.2020.1852473. Epub 2020 Dec 7.
Previous studies demonstrated that the majority of Hodgkin lymphoma (HL) patients achieve response after treatment, while 5% become refractory. Studies analyzing the role of lymphocyte subsets in peripheral blood are limited. This investigation sought to evaluate peripheral blood lymphocyte subsets and soluble MHC class I chain-related proteins A and B (sMIC-A/B) and their correlation with survival in patients with newly diagnosed HL. The study recruited 36 patients and 72 healthy donors. HL patients showed a decrease in CD4, B, monocytes, NK, and NKT cells; and an increase in γ-δ T cells and soluble MIC-A serum levels. Higher values of s-MIC- >100 ng/mL and NKT cells >40 µL correlated with poor overall survival (OS). In conclusion, in HL peripheral blood CD4 T and B cells, monocytes, NK, and NKT cells were decreased, while s-MIC-A and γ-δ T cells increased. Higher values of s-MIC-A and NKT cells correlated with poor survival.
先前的研究表明，大多数霍奇金淋巴瘤（HL）患者在治疗后会产生反应，而 5%的患者会产生耐药性。分析外周血淋巴细胞亚群作用的研究有限。本研究旨在评估新诊断 HL 患者外周血淋巴细胞亚群和可溶性 MHC Ⅰ类链相关蛋白 A 和 B（sMIC-A/B）及其与生存的相关性。该研究招募了 36 名患者和 72 名健康供体。HL 患者表现出 CD4、B、单核细胞、NK 和 NKT 细胞减少，γ-δ T 细胞和可溶性 MIC-A 血清水平增加。s-MIC- >100ng/mL 和 NKT 细胞>40µL 的更高值与总生存期（OS）不良相关。总之，HL 患者外周血 CD4 T 和 B 细胞、单核细胞、NK 和 NKT 细胞减少，而 s-MIC-A 和 γ-δ T 细胞增加。s-MIC-A 和 NKT 细胞的更高值与生存不良相关。
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