Chronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland.
University Children's Hospital Basel, University of Basel, Basel, Switzerland.
Methods Mol Biol. 2021;2130:149-156. doi: 10.1007/978-1-0716-0381-9_11.
Metabolites like melatonin are essential in determining circadian phase. In the recent years, comprehensive metabolome analyses have unveiled entire panels of small biomolecules fluctuating in a circadian fashion, thus enabling a more precise determination of inner time and understanding of how circadian clock operates at the molecular level. Emerging analytical techniques allowing for the determination of exhaled metabolites in breath show promise to gain further insights noninvasively and in vivo into circadian metabolism.
代谢产物，如褪黑素，对于确定昼夜节律相位至关重要。近年来，全面的代谢组学分析揭示了整个小分子生物分子的波动呈现出昼夜节律的方式，从而能够更精确地确定内在时间，并了解生物钟在分子水平上是如何运作的。新兴的分析技术可以在不进行侵入性和在体检测的情况下，进一步深入了解昼夜节律代谢。
