Gaugg Martin Thomas
ETH Zurich, Department of Chemistry and Applied Biosciences, Vladimir-Prelog-Weg 1-5, CH-8093 Zurich, Switzerland.
Chimia (Aarau). 2018 Apr 25;72(4):184-188. doi: 10.2533/chimia.2018.184.
Every second we are exhaling hundreds of endogenous and exogenous compounds that originate from blood and lung tissue. Obtaining metabolic information via exhaled breath analysis has been an emerging topic since the 1970s. Secondary electrospray ionization-mass spectrometry is a relatively new technique to detect these metabolites on-line in a highly sensitive and specific fashion. Using this technique, several respiratory diseases, including chronic obstructive pulmonary disease, obstructive sleep apnea, idiopathic pulmonary fibrosis, asthma, and lung cancer have been investigated over the past years. Several new potential biomarkers for these diseases were identified and new metabolic insights into their pathophysiology could be obtained.
我们每秒钟都会呼出数百种源自血液和肺组织的内源性和外源性化合物。自20世纪70年代以来，通过呼气分析获取代谢信息一直是一个新兴话题。二次电喷雾电离质谱法是一种相对较新的技术，能够以高度灵敏和特异的方式在线检测这些代谢物。在过去几年中，利用这项技术对包括慢性阻塞性肺疾病、阻塞性睡眠呼吸暂停、特发性肺纤维化、哮喘和肺癌在内的几种呼吸系统疾病进行了研究。已识别出这些疾病的几种新的潜在生物标志物，并获得了对其病理生理学的新代谢见解。
