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狭叶交让木中具有细胞毒活性的新二萜类生物碱

New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch.

作者信息

Lu Qing-Yun, Zhang Jia-Hui, Li Ying-Yao, Pu Xue-Xue, Zhang Cui-Shan, Liu Shuai, Wan Jia-Jia, Di Ying-Tong, Hao Xiao-Jiang

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.

University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2021 Aug;11(4):453-457. doi: 10.1007/s13659-021-00309-w. Epub 2021 May 11.

DOI:10.1007/s13659-021-00309-w
PMID:33977511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8275811/
Abstract

One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC of 31.9 μM.

摘要

从狭叶虎皮楠（Daphniphyllum angustifolium Hutch.）的茎部分离得到一个新的虎皮楠生物碱——虎皮楠醇A（1），以及三个已知的生物碱。通过光谱方法并与文献数据进行比较确定了它们的结构。化合物2是一种新的天然产物，但作为外消旋体已通过合成方法得到。化合物1对Hela细胞系表现出较弱的细胞毒性活性，IC50为31.9 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abb7/8275811/5d9e669de813/13659_2021_309_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abb7/8275811/d24bb39e7abb/13659_2021_309_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abb7/8275811/18466c6e1fdc/13659_2021_309_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abb7/8275811/5d9e669de813/13659_2021_309_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abb7/8275811/d24bb39e7abb/13659_2021_309_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abb7/8275811/18466c6e1fdc/13659_2021_309_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abb7/8275811/5d9e669de813/13659_2021_309_Sch1_HTML.jpg

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