Department of Paediatrics, School of Medicine, The University of Jordan, Amman, Jordan.
Department of Public Health, School of Medicine, University of Mutah, Al-Karak, Jordan.
J Int Med Res. 2020 Dec;48(12):300060520974242. doi: 10.1177/0300060520974242.
To assess serum 25-hydroxycholecalciferol (25-OH vitamin D) levels in Jordanian children with bronchial asthma, and to examine correlations between 25-OH vitamin D levels and asthma severity and control.
A cross-sectional study was conducted at the Paediatric Chest Clinic, Al-Karak Governmental Hospital, Southern Jordan, between May 2015 and February 2016. Serum 25-hydroxyvitamin D level was determined in children aged 1-14 years diagnosed with bronchial asthma (6-14 years) or recurrent wheezing episodes (<6 years). Asthma severity was determined based on the Global Initiative for Asthma assessment, the Asthma Control Test, and the Childhood Asthma Control Test. Demographic and clinical characteristics were compared between patients with low and normal 25-OH vitamin D levels, and correlations between asthma severity and 25-OH vitamin D level were assessed.
Out of 98 included children, 25-OH vitamin D levels were deficient and insufficient in 41 (41.8%) and 34 (34.7%) children, respectively. Only 23 (23.5%) had sufficient 25-OH vitamin D levels. A significant correlation was found between severity of asthma symptoms and 25-OH vitamin D deficiency.
25-OH vitamin D deficiency is highly prevalent in Jordanian children with bronchial asthma and correlates significantly with asthma severity.
评估约旦支气管哮喘儿童的血清 25-羟胆钙化醇（25-OH 维生素 D）水平，并探讨 25-OH 维生素 D 水平与哮喘严重程度和控制的相关性。
本研究为 2015 年 5 月至 2016 年 2 月在约旦南部卡拉卡政府医院儿科胸科诊所进行的横断面研究。检测了诊断为支气管哮喘（6-14 岁）或反复喘息发作（<6 岁）的 1-14 岁儿童的血清 25-羟维生素 D 水平。根据全球哮喘倡议评估、哮喘控制测试和儿童哮喘控制测试确定哮喘严重程度。比较了低和正常 25-OH 维生素 D 水平患儿的人口统计学和临床特征，并评估了哮喘严重程度与 25-OH 维生素 D 水平之间的相关性。
98 例患儿中，41 例（41.8%）和 34 例（34.7%）患儿的 25-OH 维生素 D 水平分别为缺乏和不足，仅有 23 例（23.5%）患儿的 25-OH 维生素 D 水平充足。哮喘症状严重程度与 25-OH 维生素 D 缺乏显著相关。
约旦支气管哮喘儿童中 25-OH 维生素 D 缺乏非常普遍，且与哮喘严重程度显著相关。
