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血清 25-羟维生素 D 缺乏与特应症有关,性别可能是其与巴西东北部青少年哮喘相关性的一个影响修饰因素。

Serum 25-hydroxyvitamin D deficiency is associated with atopy, and sex may be an effect modifier of its association with asthma in teenagers from northeast Brazil.

机构信息

Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, Brazil.

Instituto de Saúde Coletiva, Universidade Federal da Bahia (UFBA), Salvador, Brazil.

出版信息

Pediatr Pulmonol. 2023 Jan;58(1):297-305. doi: 10.1002/ppul.26200. Epub 2022 Nov 2.

Abstract

OBJECTIVE

Sufficient vitamin D (25-hydroxyvitamin D [25(OH)D]) serum levels are associated with decreased asthma symptoms. Our aim was to investigate associations between vitamin D and atopy, asthma, asthma severity, and asthma phenotypes in Brazilian teenagers.

METHODS

This cross-sectional study involved 942 individuals (11-19 years old) engaged in an asthma cohort. The ISAAC questionnaire was employed to diagnosis asthma and asthma severity. Serum allergen-specific immunoglobulin E (sIgE) was measured by ImmunoCap and serum 25(OH)D was measured by ELISA. We calculated the correlation between sIgE and 25(OH)D. We used multivariate logistic regression analysis to assess associations of interest.

RESULTS

We found that 25(OH)D deficiency was positively associated with atopy (OR 1.45, confidence interval [CI] 1.05-2.00) and high levels of this vitamin negatively correlated with sIgE to Dermatophagoides pteronyssinus (r = -0.11, p = 0.019). The average 25(OH)D serum level was 27.0 ± 9.5 ng/ml; 366 individuals (38.8%) had a sufficient level. There was no association between 25(OH)D and asthma, asthma severity or asthma phenotypes in the population. However, sex was a possible effect modifier of the association between vitamin D and asthma: insufficiency in asthmatic women (86%) was higher than in asthmatic men (42%), and there was an association between insufficient vitamin D levels and greater asthma risk only in women (OR = 3.06, 95% CI 1.16-8.07).

CONCLUSION

We have shown that vitamin D deficiency was associated with greater risk of atopy in both sexes and vitamin D insufficiency was associated with asthma only in women. There was no association between vitamin D levels and asthma phenotypes or asthma severity.

摘要

目的

足够的维生素 D(25-羟维生素 D [25(OH)D])血清水平与哮喘症状减轻有关。本研究旨在调查巴西青少年中维生素 D 与特应性、哮喘、哮喘严重程度和哮喘表型之间的关系。

方法

这是一项横断面研究,共纳入 942 名(11-19 岁)参与哮喘队列的个体。采用 ISAAC 问卷诊断哮喘和哮喘严重程度。通过 ImmunoCap 测定血清过敏原特异性免疫球蛋白 E(sIgE),通过 ELISA 测定血清 25(OH)D。我们计算了 sIgE 与 25(OH)D 之间的相关性。我们使用多变量逻辑回归分析评估感兴趣的关联。

结果

我们发现 25(OH)D 缺乏与特应性呈正相关(OR 1.45,95%置信区间 [CI] 1.05-2.00),并且这种维生素水平较高与屋尘螨 sIgE 呈负相关(r=-0.11,p=0.019)。血清 25(OH)D 平均水平为 27.0±9.5ng/ml;366 名(38.8%)个体 25(OH)D 水平充足。在该人群中,25(OH)D 与哮喘、哮喘严重程度或哮喘表型之间无关联。然而,性别可能是维生素 D 与哮喘之间关联的一个潜在效应修饰因子:哮喘女性(86%)的 25(OH)D 不足率高于哮喘男性(42%),且仅在女性中,维生素 D 水平不足与更大的哮喘风险之间存在关联(OR=3.06,95%CI 1.16-8.07)。

结论

我们的研究表明,维生素 D 缺乏与两性的特应性风险增加有关,而维生素 D 不足仅与女性的哮喘有关。维生素 D 水平与哮喘表型或哮喘严重程度之间无关联。

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