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Teprenone for the prevention of low-dose aspirin-induced gastric mucosal injury in -negative patients.替普瑞酮预防幽门螺杆菌阴性患者低剂量阿司匹林所致胃黏膜损伤的研究
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Evaluation of milk fat globule-epidermal growth factor-factor VIII and IL-1β levels in gingival crevicular fluid and saliva in periodontal disease and health.评价牙周病和健康状态下龈沟液和唾液中乳脂肪球-表皮生长因子因子 VIII 和白细胞介素-1β的水平。
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Protective effect of polaprezinc on acute gastric mucosal injury in rats.聚普瑞锌对大鼠急性胃黏膜损伤的保护作用。
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水浸束缚应激对去唾液腺大鼠胃黏膜的影响。

Effect of water immersion restraint stress on gastric mucosa in rats with removed salivary glands.

作者信息

Xu Bo, Cui Xiao, Xu Kui, Lin Lin, Zhou Yanbing

机构信息

Department of General Surgery, Red Cross Central Hospital of Harbin Harbin, Heilongjiang Province, China.

Department of General Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong Province, China.

出版信息

Int J Clin Exp Pathol. 2020 Nov 1;13(11):2853-2859. eCollection 2020.

PMID:33284885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7716124/
Abstract

OBJECTIVE

To explore the effect of salivary gland removal on water immersion restraint stress (WIRS)-induced gastric mucosal injury (GMI) in rats.

METHODS

Eighty male WISTAR rats were allocated into sham operation (sham) group, sham + WIRS group, salivary gland removal group, and salivary gland removal + WIRS group, with 20 rats in each group. In the sham group, skin and subcutaneous tissues were cut to expose glands. The rats in other three groups were subjected to a total salivary gland resection, and all their submandibular glands and sublingual glands and part of the parotid glands were removed, and the parotid duct was ligated. Afterwards, rats were exposed to WIRS for one and a half months and sacrificed. The severity of GMI was scored, and any histologic and ultrastructural changes were monitored.

RESULTS

There were differences in the Guth index (GMI evaluation) scores among the four groups (P=0.000), which were higher in salivary gland removal + WIRS group than those in the other three groups (all P<0.001), and were higher in the sham + WIRS group and salivary gland removal group than those in the sham group (all P=0.000). Compared with other groups, the gastric mucosa was severely injured in the salivary gland removal + WIRS group, with obvious congestion, edema, inflammatory cell infiltrate, mucosal shedding, bleeding ulcers, enlarged intercellular spaces, and damaged organelles.

CONCLUSION

Salivary gland removal aggravates WIRS-induced GMI to a certain extent.

摘要

目的

探讨摘除唾液腺对水浸束缚应激（WIRS）诱导的大鼠胃黏膜损伤（GMI）的影响。

方法

将80只雄性WISTAR大鼠分为假手术（sham）组、假手术+WIRS组、唾液腺摘除组和唾液腺摘除+WIRS组，每组20只。假手术组切开皮肤和皮下组织暴露腺体。其他三组大鼠进行唾液腺全切除，切除所有下颌下腺、舌下腺及部分腮腺，并结扎腮腺导管。之后，将大鼠暴露于WIRS环境中1个半月后处死。对GMI的严重程度进行评分，并监测任何组织学和超微结构变化。

结果

四组的Guth指数（GMI评估）评分存在差异（P=0.000），唾液腺摘除+WIRS组高于其他三组（均P<0.001），假手术+WIRS组和唾液腺摘除组高于假手术组（均P=0.000）。与其他组相比，唾液腺摘除+WIRS组胃黏膜损伤严重，有明显充血、水肿、炎性细胞浸润、黏膜脱落、出血性溃疡、细胞间隙增宽和细胞器损伤。

结论

摘除唾液腺在一定程度上加重WIRS诱导的GMI。