College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P.R. China.
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P.R. China.
Org Lett. 2020 Dec 18;22(24):9762-9766. doi: 10.1021/acs.orglett.0c03860. Epub 2020 Dec 7.
Herein, we report a new method for the synthesis of acyethanethioates via thiocarbonylation of -difluoroalkenes with thiols. This reaction provides a new pathway to prepare thioesters under mild conditions without the use of any additives. Mechanistic studies revealed that in situ generated HF facilitated the C-F bond cleavage in an autocatalytic manner.
在此，我们报告了一种通过二氟烯烃与硫醇的硫羰化反应合成乙硫代乙酰胺硫酯的新方法。该反应在温和条件下无需使用任何添加剂即可提供一条合成硫酯的新途径。机理研究表明，原位生成的 HF 以自催化的方式促进 C-F 键断裂。
