Fernández M, Wong E, Oehling A
Department of Allergology, Faculty of Medicine, University of Navarra, Pamplona, Spain.
Allergol Immunopathol (Madr). 1987 Nov-Dec;15(6):369-73.
There is no doubt that ketotifen has continued to be an effective prophylactic anti-allergic drug throughout the years since its discovery. Therefore, we decided to perform a retrospective study of this pharmacologic agent to evaluate its efficacy, duration of treatment, as well as its tolerance in different allergic processes. A total of 1,000 histories of allergic patients were reviewed and 450 were selected by chance from 1981 through 1984. The patients were divided as to their diagnostic etiology, whether affected by pollen or house dust. Ketotifen efficacy was graded from 0-3 (bad, regular, good and excellent), according to its clinical evaluation. In general, children responded better to ketotifen treatment than adults (reduction in other symptomatic drug intake), although statistical significance was found in both populations. However, drug efficacy was better in pollen than house dust. Induced asthma and rhinitis in the children population. On the other hand, no statistical difference was found between sensitization to house dust or pollens in the adult population. To be truly effective, ketotifen should be taken for at least 3 months or more. We only found 12 (2.66%) patients who presented somnolence: the rest tolerated the drug well, with no secondary side effects.
毫无疑问，自发现以来的这些年里，酮替芬一直是一种有效的预防性抗过敏药物。因此，我们决定对这种药物进行一项回顾性研究，以评估其疗效、治疗持续时间以及在不同过敏过程中的耐受性。总共回顾了1000例过敏患者的病史，并在1981年至1984年间随机选择了450例。根据诊断病因将患者分为受花粉或屋尘影响两类。根据临床评估，酮替芬的疗效分为0 - 3级（差、一般、良好和优秀）。总体而言，儿童对酮替芬治疗的反应比成人更好（其他对症药物摄入量减少），尽管在这两个人群中均发现有统计学意义。然而，药物对花粉的疗效比对屋尘更好。在儿童人群中诱发哮喘和鼻炎。另一方面，在成人人群中，对屋尘或花粉过敏之间未发现统计学差异。为了真正有效，酮替芬应服用至少3个月或更长时间。我们仅发现12例（2.66%）患者出现嗜睡：其余患者对药物耐受性良好，无继发性副作用。
