State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, HKSAR, China; State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, HKSAR, China.
Pharmacol Res. 2021 Feb;164:105321. doi: 10.1016/j.phrs.2020.105321. Epub 2020 Dec 5.
Breast cancer is an inflammation-related cancer whose tumor microenvironment is largely infiltrated by inflammatory cells. These inflammatory cells including mast cells and macrophages have been elucidated to be vital participants in breast tumor proliferation, survival, invasion and migration. However, the functions of mast cells and macrophages in breast cancer are quite distinct based on recent data. Mast cells exhibit both anti-tumoral and pro-tumoral functions on breast cancer, while high number of tumor-associated macrophages (TAMs) are strongly correlated with poor prognosis and higher risk of distant metastasis in breast cancer patients. Besides, many natural products/extracts have been reported to regulate mast cells and macrophages. In this review, the roles of mast cells and macrophages play in breast cancer are discussed and a summary of those natural products/herbs regulating the functions of mast cells or macrophages is also presented.
乳腺癌是一种与炎症相关的癌症，其肿瘤微环境中大量浸润着炎症细胞。这些炎症细胞，包括肥大细胞和巨噬细胞，已经被阐明是乳腺癌增殖、存活、侵袭和迁移的重要参与者。然而，根据最近的数据，肥大细胞和巨噬细胞在乳腺癌中的功能是截然不同的。肥大细胞在乳腺癌中表现出既具有抗肿瘤作用又具有促肿瘤作用，而大量的肿瘤相关巨噬细胞（TAMs）与乳腺癌患者预后不良和远处转移风险增加密切相关。此外，许多天然产物/提取物已被报道可调节肥大细胞和巨噬细胞。在这篇综述中，讨论了肥大细胞和巨噬细胞在乳腺癌中的作用，并总结了那些调节肥大细胞或巨噬细胞功能的天然产物/草药。
