Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China.
Pediatric Intensive Care Unit, Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.
J Am Acad Dermatol. 2021 May;84(5):1378-1384. doi: 10.1016/j.jaad.2020.11.062. Epub 2020 Dec 4.
Abdominal ultrasonography has been proposed to screen for infantile hepatic hemangioma (IHH) in patients with multiple cutaneous infantile hemangiomas (IHs).
The aim of this study was to establish the optimal cutoff point for the number of cutaneous IHs needed to screen for IHH.
We performed a prospective, multicenter study to screen for IHH in patients younger than 9 months who had multiple cutaneous IHs (n ≥ 3) on ultrasonography. For comparison, a group of patients with 1 or 2 focal cutaneous IHs was also recruited.
In total, 676 patients with at least 3 cutaneous IHs and 980 patients with 1 or 2 focal cutaneous IHs were enrolled. Thirty-one patients were found to have IHH. A higher number of cutaneous IHs was associated with an increased risk of IHH (R = 0.973; P < .001). Receiver operating characteristic curve analysis showed that 5 cutaneous IHs was the optimal cutoff point to screen for IHH, with an area under the curve of 0.872 (P < .001; 95% confidence interval, 0.789-0.955).
This was an uncontrolled study.
Screening for IHH is recommended in patients younger than 9 months who present with 5 or more cutaneous IHs.
腹部超声检查被提议用于筛查多发性皮肤婴幼儿血管瘤（IHH）患者的婴幼儿肝血管瘤（IHH）。
本研究旨在确定需要筛查 IHH 的皮肤 IHH 数量的最佳截止点。
我们进行了一项前瞻性、多中心研究，以筛查超声检查显示有≥3 个皮肤 IHH 的 9 个月以下的 IHH 患者。为了比较，还招募了一组有 1 或 2 个局灶性皮肤 IHH 的患者。
共有 676 例至少有 3 个皮肤 IHH 的患者和 980 例有 1 或 2 个局灶性皮肤 IHH 的患者被纳入。发现 31 例患有 IHH。更多的皮肤 IHH 与 IHH 的风险增加相关（R=0.973；P<0.001）。受试者工作特征曲线分析显示，5 个皮肤 IHH 是筛查 IHH 的最佳截止点，曲线下面积为 0.872（P<0.001；95%置信区间，0.789-0.955）。
这是一项非对照研究。
建议对有 5 个或更多皮肤 IHH 的 9 个月以下患者进行 IHH 筛查。
