Yang Luyao, Dou Weitao, Chen Xin, Teng Jianbo, Wei Xinhong
Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Department of Medical Intervention, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Front Oncol. 2025 Jul 2;15:1508461. doi: 10.3389/fonc.2025.1508461. eCollection 2025.
This study aimed to analyze and summarize the prenatal and postnatal imaging findings, as well as the postnatal growth curves, of patients with hepatic hemangiomas (HHs) that were identified and continued to proliferate after birth.
A retrospective study was conducted to collect and analyze data from children with congenital hepatic hemangiomas (CHH) who were diagnosed and followed-up at our hospital between January 1, 2016 and December 30, 2023. These children exhibited rapid postnatal proliferation of lesions, followed by spontaneous regression. The study recorded the patients' general clinical information, laboratory test results, and pre- and postnatal imaging characteristics of the tumor, as well as changes in tumor volume over time.
Eight patients (four males and four females) were included in this group, with and average gestational age of 37 weeks at the initial onset. The imaging features of this type of hepatic hemangioma are almost indistinguishable from those previously described for CHH. The only difference was that 87.5% of the tumors were located in the left lobe of the liver, and no calcification was observed within the tumors during the prenatal and proliferative stages. The postnatal growth trend of the tumors was very rapid, with complete proliferation occurring within the first six months after birth (median, 66 days) and the peak volume exceeding 1.5 × the initial volume. Of the tumors, 87.5% (7/8) regressed to 80% of the initial volume within one year, and the median time to complete regression was 365 days (range 300-730). None of the patients experienced adverse symptoms or complications during the study period.
This article describes a special type of CHH that can continue to proliferate after birth. However, the tumor spontaneously regresses over time without complications. Therefore, for postnatal CHH growth, regular imaging observation without drug treatment or surgery is recommended, thereby preventing overtreatment while ensuring normal child development.
本研究旨在分析和总结出生后被发现并持续增殖的肝血管瘤（HHs）患者的产前和产后影像学表现以及产后生长曲线。
进行一项回顾性研究，收集并分析2016年1月1日至2023年12月30日在我院诊断并随访的先天性肝血管瘤（CHH）患儿的数据。这些患儿出生后病变迅速增殖，随后自发消退。研究记录了患者的一般临床信息、实验室检查结果、肿瘤的产前和产后影像学特征以及肿瘤体积随时间的变化。
该组纳入8例患者（4例男性和4例女性），初发时平均孕周为37周。这种类型的肝血管瘤的影像学特征与先前描述的CHH几乎无法区分。唯一的区别是87.5%的肿瘤位于肝左叶，产前和增殖期肿瘤内未观察到钙化。肿瘤的产后生长趋势非常迅速，在出生后的前六个月内（中位数为66天）完全增殖，峰值体积超过初始体积的1.5倍。其中87.5%（7/8）的肿瘤在一年内消退至初始体积的80%，完全消退的中位时间为365天（范围300 - 730天）。研究期间所有患者均未出现不良症状或并发症。
本文描述了一种特殊类型的CHH，其在出生后可继续增殖。然而，肿瘤会随时间自发消退且无并发症。因此，对于出生后CHH的生长，建议定期进行影像学观察，无需药物治疗或手术，从而在确保儿童正常发育的同时避免过度治疗。
