School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland; Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; Trinity St. James's Cancer Institute, Trinity College Dublin, Ireland.
School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland; Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; Trinity St. James's Cancer Institute, Trinity College Dublin, Ireland.
Drug Discov Today. 2021 Mar;26(3):778-785. doi: 10.1016/j.drudis.2020.11.001. Epub 2020 Dec 4.
Extracellular vesicles (EVs), often described as mini-maps of their cells of origin, are found in the bloodstream and can be rich sources of cargo released from cancer cells. As such, they could be collected through minimally invasive methods and potentially used as biomarkers. However, the relatively complicated methodologies that separate the purest EVs are the least likely to be translated to the clinic, whereas simpler methods are non-selective for EVs. Notwithstanding this, research is underway to identify blood-based EV-associated diagnostic and predictive biomarkers for breast cancer. There is reason to be optimistic that some approaches will yield useful biomarkers. Thus, further studies with larger cohorts of appropriate samples are warranted.
细胞外囊泡（EVs），通常被描述为其起源细胞的迷你图谱，存在于血液中，并且可以作为癌细胞释放的货物的丰富来源。因此，它们可以通过微创方法收集，并可能用作生物标志物。然而，将最纯净的 EV 分离出来的相对复杂的方法不太可能转化为临床应用，而更简单的方法则对 EV 没有选择性。尽管如此，仍在进行研究以确定用于乳腺癌的基于血液的 EV 相关诊断和预测生物标志物。有理由乐观地认为一些方法将产生有用的生物标志物。因此，需要对具有适当样本的更大队列进行进一步研究。
