Department of Obstetrics and Gynecology, Hospital Universitario General de Villalba, Madrid, Spain.
Department of Obstetrics and Gynecology, Hospital Universitario General de Villalba, Madrid, Spain.
Eur J Obstet Gynecol Reprod Biol. 2021 Jan;256:400-404. doi: 10.1016/j.ejogrb.2020.11.069. Epub 2020 Dec 1.
To screen pregnant women at risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during delivery using reverse-transcription polymerase chain reaction (RT-PCR) test and serum immunoglobulin (Ig) testing.
Between March 31 st and August 31 st of 2020, consecutive pregnant women admitted for labor and delivery in a single hospital were screened for SARS-CoV-2 with nasopharyngeal RT-PCR swab tests and detection of serum IgG and IgM.
We studied 266 pregnant women admitted for labor and delivery. The prevalence of acute or past SARS-CoV-2 infection was 9.0 %, including (i) two cases with respiratory symptoms of SARS-Co-V-2 infection and positive RT-PCR; (ii) four asymptomatic women with positive RT-PCR without clinical symptoms and negative serological tests between two and 15 weeks later; and (iii) two women with false positive RT-PCR due to technical problems. All newborns of the 6 pregnant women with RT-PCR positive had negative RT-PCR and did not require Neonatal Intensive Care Unit admission. There were eighteen asymptomatic women with positive serological IgG tests and negative RT-PCR.
In our cohort of gravids, we found 2.2 % of women with positive RT-PRC tests and 6.7 % with positive serological tests during the first wave of the SARS-CoV-2 pandemic.
通过逆转录聚合酶链反应（RT-PCR）检测和血清免疫球蛋白（Ig）检测，筛选分娩时感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）风险高的孕妇。
2020 年 3 月 31 日至 8 月 31 日，对一家医院连续收治的临产孕妇进行 SARS-CoV-2 鼻咽 RT-PCR 拭子检测和血清 IgG、IgM 检测。
我们研究了 266 例临产孕妇。急性或既往 SARS-CoV-2 感染的患病率为 9.0%，包括：（i）2 例有 SARS-Co-V-2 感染呼吸道症状且 RT-PCR 阳性；（ii）4 例无症状女性 RT-PCR 阳性但无临床症状，两周后复查血清学 IgG、IgM 均阴性；（iii）2 例因技术问题 RT-PCR 假阳性。6 例 RT-PCR 阳性孕妇所生的新生儿 RT-PCR 均为阴性，无需入住新生儿重症监护病房。有 18 例无症状孕妇血清 IgG 检测阳性但 RT-PCR 阴性。
在我们的孕妇队列中，在 SARS-CoV-2 大流行的第一波中，我们发现有 2.2%的孕妇 RT-PCR 检测阳性，6.7%的孕妇血清学 IgG 检测阳性。
