Shen Zhen, Chen Zehua, Xie Zhuoting, Xu Yanfei, Wang Tao, Li Jiao, Yuan Changfei, Liu Jinqing, Shi Xiaodong, Ai Yuanliang, Dong Wei, Guo Ying
Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China.
The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming, China.
Medicine (Baltimore). 2020 Dec 4;99(49):e23123. doi: 10.1097/MD.0000000000023123.
Bisphosphonates are commonly used to treat spontaneous osteonecrosis of the knee (SONK), while there are no relevant systematic review or meta-analysis designed to evaluate the effects of bisphosphonates on SONK.
We will identify relevant randomized controlled trials from the PubMed, EMBASE, CINAHL and China National Knowledge Infrastructure, up to March 20, 2020. Data that meets the inclusion criteria will be extracted and analyzed using RevMan V.5.3 software. Two reviewers will assess quality of the included studies by using the Cochrane Collaboration risk of bias tool. Egger test and Begg test will be used to evaluate publication bias. And Grading of Recommendations Assessment, Development and Evaluation will be employed to assess the quality of evidence.
In this study, we will analyze the effect of bisphosphonates on pain intensity, physical function, biochemical including alkaline phosphatase, N-terminal propeptide of type I procollagen, and C-terminal type I collagen telopeptide, radiological outcome (evaluated by using Magnetic resonance imaging) and ratio of secondary surgery for patients with SONK.
Our findings will provide evidence for the effectiveness and potential treatment prescriptions of bisphosphonates acupuncture for patients affected by SONK.
双膦酸盐常用于治疗膝关节自发性骨坏死（SONK），但尚无相关系统评价或荟萃分析来评估双膦酸盐对SONK的疗效。
我们将从PubMed、EMBASE、CINAHL和中国知网中检索截至2020年3月20日的相关随机对照试验。符合纳入标准的数据将使用RevMan V.5.3软件进行提取和分析。两名评价者将使用Cochrane协作网偏倚风险工具评估纳入研究的质量。采用Egger检验和Begg检验评估发表偏倚。并采用推荐意见评估、制定与评价分级系统来评估证据质量。
在本研究中，我们将分析双膦酸盐对SONK患者疼痛强度、身体功能、生化指标（包括碱性磷酸酶、I型前胶原氨基端前肽和I型胶原羧基端肽）、影像学结果（通过磁共振成像评估）以及二次手术比例的影响。
我们的研究结果将为双膦酸盐针灸治疗SONK患者的有效性和潜在治疗方案提供证据。
