The Fifth Clinical Medical School, Guangzhou University of Chinese Medicine.
Kunming Municipal Hospital of Traditional Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming.
Medicine (Baltimore). 2021 Jan 29;100(4):e23891. doi: 10.1097/MD.0000000000023891.
Electroacupuncture is increasingly used in rehabilitation for postoperative cognitive dysfunction (POCD), but relevant evidence remains unclear for patients receiving total knee arthroplasty (TKA).
The databases research of PubMed, EMBASE, CINAHL, and China National Knowledge Infrastructure (CNKI) will be conducted from inception to December 31, 2020. The relevant randomized controlled trials (RCTs) from data will be screened one by one. The remaining studies that meet the inclusion criteria will be extracted and analyzed using RevMan V.5.3 software. Paired 2 reviewers will assess quality of the included studies and publication bias by using the Cochrane Collaboration risk of bias tool, and Egger test and Begg test respectively. And grading of recommendations assessment, development and evaluation (GRADE) will be used to estimate the quality of evidence.
In this study, we will analyze the effect of electroacupuncture on Mini-Mental State Examination (MMSE), interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α), S100-β protein, and adverse events for patients with TKA.
Our findings will provide evidence for the effectiveness of electroacupuncture on the treatment and prevention of POCD for TKA patients.
Available at: https://osf.io/azyt9 (DOI number: 10.17605/OSF.IO/AZYT9).
电针在术后认知功能障碍（POCD）的康复中应用越来越广泛，但对于接受全膝关节置换术（TKA）的患者，相关证据仍不明确。
从建库至 2020 年 12 月 31 日，检索 PubMed、EMBASE、CINAHL 和中国知网（CNKI）数据库，对筛选出的文献进行逐一阅读，提取并采用 RevMan V.5.3 软件分析符合纳入标准的研究。采用 Cochrane 协作网偏倚风险评估工具对纳入研究进行质量评价，采用 Egger 检验和 Begg 检验进行发表偏倚评估。采用推荐意见的评估、制定与评价（GRADE）分级对证据质量进行评价。
本研究将分析电针对 TKA 患者 MMSE、白细胞介素 1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、S100-β 蛋白及不良反应的影响。
本研究结果将为电针对 TKA 患者 POCD 的治疗和预防提供证据。
可在以下网址获取：https://osf.io/azyt9（DOI 编号：10.17605/OSF.IO/AZYT9）。
