Wang Chunyue, Cao Yana, Chen Xi, Cai Mingming, Huang Wei
Department of Ophthalmology, The Ninth People's Hospital of Chongqing, Beibei.
Department of Ophthalmology, Chungking General Hospital, Yubei.
Medicine (Baltimore). 2020 Dec 4;99(49):e23131. doi: 10.1097/MD.0000000000023131.
A cataract is a degenerative change in the optical quality of the lens caused by protein denaturation. Modern medicine is mainly based on surgical treatment. Cataract surgery is often accompanied by severe inflammation, and glucocorticoid therapy has many adverse reactions and side effects. The non-steroidal anti-inflammatory drug sodium bromfenac not only has good anti-inflammatory, analgesic and anti-allergic effects, but also does not produce side effects caused by hormone drugs. Clinical studies have shown that sodium bromfenac eye drops have a good curative effect in treating postoperative inflammation of cataract, with low recurrence rate and certain therapeutic advantages, but lack of evidence-based medicine evidence. The purpose of this study is to systematically evaluate the efficacy and safety of sodium bromfenac eye drops in the treatment of postoperative inflammation of cataracts.
Use computer to search English and Chinese databases, such as PubMed, Embase, Web of Science, the Cochrane Library, CNKI, Wanfang, Weipu, China Biomedical Database, and Chinese Clinical Trial Registry for randomized controlled trials on the treatment of postoperative postoperative inflammation in cataract surgery with sodium bromfenac eye drops from the establishment of the database to September 2020, and data extraction and literature quality evaluation were conducted independently by two researchers, and Meta analysis was conducted on the included literature using RevMan5.3 software.
In this study, the efficacy and safety of sodium bromfenac eye drops in the treatment of postoperative inflammation of cataract surgery were evaluated by the effective rate, symptom score, adverse reactions, incidence, recurrence rate, etc. CONCLUSION:: This study will provide reliable evidence-based evidence for the clinical application of bromofenac sodium eye drops in the treatment of postoperative inflammation of cataract.
DOI 10.17605/OSF.IO/3KP7R.
白内障是由蛋白质变性引起的晶状体光学质量的退行性改变。现代医学主要基于手术治疗。白内障手术常伴有严重炎症，糖皮质激素治疗有许多不良反应和副作用。非甾体抗炎药溴芬酸钠不仅具有良好的抗炎、镇痛和抗过敏作用，而且不会产生激素药物引起的副作用。临床研究表明，溴芬酸钠滴眼液治疗白内障术后炎症疗效良好，复发率低，具有一定的治疗优势，但缺乏循证医学证据。本研究旨在系统评价溴芬酸钠滴眼液治疗白内障术后炎症的疗效和安全性。
利用计算机检索英文和中文数据库，如PubMed、Embase、Web of Science、Cochrane图书馆、CNKI、万方、维普、中国生物医学数据库和中国临床试验注册中心，检索从数据库建立至2020年9月用溴芬酸钠滴眼液治疗白内障手术术后炎症的随机对照试验，由两名研究人员独立进行数据提取和文献质量评价，并使用RevMan5.3软件对纳入文献进行Meta分析。
本研究通过有效率、症状评分、不良反应、发生率、复发率等对溴芬酸钠滴眼液治疗白内障手术术后炎症的疗效和安全性进行评价。结论：本研究将为溴芬酸钠滴眼液治疗白内障术后炎症的临床应用提供可靠的循证依据。
DOI 10.17605/OSF.IO/3KP7R。
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