State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .
J Ocul Pharmacol Ther. 2017 Apr;33(3):193-201. doi: 10.1089/jop.2016.0114. Epub 2017 Jan 20.
The purpose of this study was to evaluate the effect of topical 0.1% bromfenac sodium, a nonsteroidal anti-inflammatory drug (NSAID), on intraoperative pupil dilation maintenance and prostaglandin E (PGE) inhibition during femtosecond laser-assisted cataract surgery.
Sixty patients (30 each in study and control groups) were included in this study. The patients received 0.1% bromfenac ophthalmic solution or control placebo twice a day for 3 days before surgery. Pupil size was measured at the initiation of femtosecond laser pretreatment and phacoemulsification. Aqueous humor was collected at the beginning of routine cataract surgery. PGE levels were measured with an enzyme-linked immunoassay. Laser flare photometry was measured preoperatively and at 1 day postoperatively.
Compared with untreated patients, the change in pupil size and postoperative day 1 aqueous flare were significantly reduced throughout the operation in the patients treated with 0.1% bromfenac (P < 0.001). Mean PGE concentrations were also significantly decreased by treatment with 0.1% bromfenac (P < 0.001). The reduction of the pupil area and postoperative day 1 aqueous flare were significantly correlated with PGE levels (P < 0.001).
NSAID treatment, when administered before femtosecond laser-assisted cataract surgery, was effective in maintaining intraoperative pupil dilation, preventing miosis, and reducing PGE levels.
本研究旨在评估非甾体抗炎药（NSAID）0.1%溴芬酸钠滴眼剂对飞秒激光辅助白内障手术中术中瞳孔扩张维持和前列腺素 E（PGE）抑制的影响。
本研究纳入 60 例患者（每组 30 例）。患者在手术前 3 天每天接受 0.1%溴芬酸钠滴眼液或对照安慰剂滴眼 2 次。在飞秒激光预处理和超声乳化开始时测量瞳孔大小。在常规白内障手术开始时收集房水。采用酶联免疫吸附试验测量 PGE 水平。在术前和术后 1 天进行激光闪烁光度测定。
与未治疗的患者相比，在接受 0.1%溴芬酸钠治疗的患者中，整个手术过程中瞳孔大小的变化和术后第 1 天房水闪烁均显著减少（P<0.001）。用 0.1%溴芬酸钠治疗后 PGE 浓度也显著降低（P<0.001）。瞳孔面积的减少和术后第 1 天房水闪烁与 PGE 水平显著相关（P<0.001）。
在飞秒激光辅助白内障手术前给予 NSAID 治疗，可有效维持术中瞳孔扩张、预防瞳孔缩小和降低 PGE 水平。
