鼻窦神经内分泌癌伴抗利尿激素分泌异常综合征
Sinonasal neuroendocrine carcinoma in association with SIADH.
作者信息
Vasan Nilesh R, Medina Jesus E, Canfield Vikki A, Gillies Elizabeth M
机构信息
Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, P.O. Box 26901, WP 1360, Oklahoma City, Oklahoma 73190, USA.
出版信息
Head Neck. 2004 Jan;26(1):89-93. doi: 10.1002/hed.10345.
BACKGROUND
Neuroendocrine carcinoma (NEC) is a rare malignancy of the nasal cavity or paranasal sinuses. The syndrome of inappropriate ADH secretion (SIADH) has not been previously reported in association with this cancer.
METHODS
We report a 30-year-old woman with histologically confirmed neuroendocrine carcinoma who also demonstrated SIADH. After successful chemotherapy and radiotherapy treatment for the neoplasm, her SIADH resolved. A literature search found eight cases of olfactory neuroblastoma (ONB) associated with SIADH, four of which resolved after treatment of the malignancy.
RESULTS
Treatment of the underlying malignancy resulted in the immediate resolution of the SIADH.
CONCLUSIONS
We report the first case of SIADH associated with NEC, which resolved after treatment of the cancer. A direct cause and effect between ONB/nasal NEC and SIADH has been established in previous reports.
背景
神经内分泌癌（NEC）是鼻腔或鼻窦的一种罕见恶性肿瘤。此前尚未有与这种癌症相关的抗利尿激素分泌不当综合征（SIADH）的报道。
方法
我们报告一名30岁组织学确诊为神经内分泌癌且伴有SIADH的女性。对该肿瘤成功进行化疗和放疗后，她的SIADH症状消失。文献检索发现8例与SIADH相关的嗅神经母细胞瘤（ONB），其中4例在恶性肿瘤治疗后症状消失。
结果
对潜在恶性肿瘤的治疗使SIADH立即得到缓解。
结论
我们报告了首例与NEC相关的SIADH，在癌症治疗后症状消失。此前的报道已证实ONB/鼻腔NEC与SIADH之间存在直接因果关系。
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