Dal Lin Carlo, Brugnolo Laura, Marinova Mariela, Plebani Mario, Iliceto Sabino, Tona Francesco, Vitiello Giuseppe
Department of Cardiac, Thoracic and Vascular Sciences, Padua University Medical School, Via Giustiniani 2, 35100 Padua, Italy.
Department of Laboratory Medicine, Padua University Medical School, Via Giustiniani 2, 35100 Padua, Italy.
Entropy (Basel). 2020 Jul 27;22(8):818. doi: 10.3390/e22080818.
Stress appears to be the basis of many diseases, especially myocardial infarction. Events are not objectively "stressful" but what is central is how the individual structures the experience he is facing: the thoughts he produces about an event put him under stress. This cognitive process could be revealed by language (words and structure). We followed 90 patients with ischemic heart disease and 30 healthy volunteers, after having taught them the Relaxation Response (RR) as part of a 4-day Rational-Emotional-Education intervention. We analyzed with the Linguistic Inquiry and Word Count software the words that the subjects used across the study following the progression of blood galectin-3 (inflammation marker) and malondialdehyde (oxidative stress marker). During the follow-up, we confirmed an acute and chronic decrease in the markers of inflammation and oxidative stress already highlighted in our previous studies together with a significant change in the use of language by the subjects of the RR groups. Our results and the precise design of our study would seem to suggest the existence of an intimate relationship and regulatory action by cognitive processes (recognizable by the type of language used) on some molecular processes in the human body.
压力似乎是许多疾病的基础，尤其是心肌梗死。事件本身并非客观上“有压力”，关键在于个体如何构建他所面临的经历：他对某一事件产生的想法会使他处于压力之下。这种认知过程可以通过语言（词汇和结构）体现出来。我们对90名缺血性心脏病患者和30名健康志愿者进行了跟踪研究，此前我们对他们进行了为期4天的理性情绪教育干预，其中包括教授他们放松反应（RR）。我们使用语言查询与字数统计软件，根据血液中半乳糖凝集素-3（炎症标志物）和丙二醛（氧化应激标志物）的变化过程，分析了研究对象在整个研究过程中使用的词汇。在随访期间，我们证实了炎症和氧化应激标志物的急性和慢性下降，这在我们之前的研究中就已得到强调，同时RR组研究对象的语言使用也发生了显著变化。我们的研究结果以及研究的精确设计似乎表明，认知过程（可通过所用语言类型识别）与人体某些分子过程之间存在密切关系和调节作用。
