Korakiti Anna-Maria, Zografos Eleni, van Gerwen Mathilde, Amant Frédéric, Dimopoulos Meletios-Athanasios, Zagouri Flora
Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Center for Gynecologic Oncology Amsterdam, Antoni van Leeuwenhoek-Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Cancers (Basel). 2020 Dec 3;12(12):3623. doi: 10.3390/cancers12123623.
Pregnancy-related cancer management represents a real challenge for both the patients and the physicians. The long-term neurodevelopmental outcome of children in utero exposed to chemotherapeutic agents has only recently been addressed. This review aims to systematically integrate and highlight all existing data from the literature regarding the effect of prenatal exposure to chemotherapy on fetal brain growth and child development. All eligible studies are based on validated neurodevelopmental testing scales (e.g., Bayley Scales of Infant Development, Wechsler Preschool and Primary Scale of Intelligence) and/or well-defined questionnaires. Our systematic review including 17 studies demonstrates that no major consequences on the neurodevelopment of children after in utero exposure to anti-cancer drugs have been reported; nevertheless, longer and more thorough follow-up with large-scale multicenter prospective studies is certainly required in order to draw firm conclusions.
妊娠相关癌症的管理对患者和医生来说都是一项真正的挑战。子宫内接触化疗药物的儿童的长期神经发育结果直到最近才得到关注。这篇综述旨在系统地整合和突出文献中所有关于产前接触化疗对胎儿大脑生长和儿童发育影响的现有数据。所有符合条件的研究均基于经过验证的神经发育测试量表（如贝利婴儿发育量表、韦氏学前和初智量表）和/或定义明确的问卷。我们纳入17项研究的系统综述表明，尚无报告称子宫内接触抗癌药物会对儿童神经发育产生重大后果；然而，为了得出确凿的结论，确实需要通过大规模多中心前瞻性研究进行更长时间、更全面的随访。
