Long Noncoding RNA Promotes Progression and Predicts Patient Prognosis in Human Ovarian Cancer.

(1) Background: LncRNAs could be a promising biomarker to predict the prognosis of various cancers. The significance of lncRNA remains unclear in cancer. In this study, we examined the expression level of in the serum of ovarian cancer patients and the functional role of . (2) Methods: Serum samples were obtained from 108 OC patients and 32 normal patients to measure the expression of in the serum. Ovarian cancer cells were used to investigate the role of in cell proliferation, invasion, migration and apoptosis, and the expression of was knocked down using RNA interference. In addition, knockdown cell lines were used in in vivo experiments. (3) Results: The expression of was significantly higher in the serum of OC patients than in that of control patients ( < 0.05). The knockdown of in ovarian cancer cells led to a decrease in cell proliferation, invasion and migration and an increase in apoptosis. knockdown also reduced the expression of epithelium-mesenchymal metastasis (EMT) genes. (4) Conclusion: These findings highlight the clinical significance of in predicting the prognosis of OC patients and suggest its potential in promoting tumour aggressiveness by the regulation of EMT-related mechanisms.