Davisson M T
Jackson Laboratory, Bar Harbor, Maine 04609.
Genomics. 1987 Nov;1(3):213-27. doi: 10.1016/0888-7543(87)90047-4.
X-linked genes are conserved among all mammalian species, but the organization of genes on the X chromosome varies from one species to another. This review summarizes the evidence for established gene homologies between mice and human beings. It also describes genes that are possible homologies because of their locations in the human and murine X chromosomes and similarities in the phenotypes they produce. Based on current knowledge of homologous gene location, the human and murine X chromosomes appear to contain four highly conserved segments and differ in organization by only three to four simple chromosomal rearrangements.
X连锁基因在所有哺乳动物物种中都是保守的，但X染色体上基因的组织方式因物种而异。这篇综述总结了小鼠和人类之间已确定的基因同源性的证据。它还描述了由于其在人类和小鼠X染色体上的位置以及它们产生的表型相似性而可能存在同源性的基因。根据目前对同源基因位置的了解，人类和小鼠的X染色体似乎包含四个高度保守的片段，并且在组织上仅通过三到四次简单的染色体重排而有所不同。
