自人类和小鼠分化以来保守的染色体片段长度。
Lengths of chromosomal segments conserved since divergence of man and mouse.
作者信息
Nadeau J H, Taylor B A
出版信息
Proc Natl Acad Sci U S A. 1984 Feb;81(3):814-8. doi: 10.1073/pnas.81.3.814.
Linkage relationships of homologous loci in man and mouse were used to estimate the mean length of autosomal segments conserved during evolution. Comparison of the locations of greater than 83 homologous loci revealed 13 conserved segments. Map distances between the outermost markers of these 13 segments are known for the mouse and range from 1 to 24 centimorgans. Methods were developed for using this sample of conserved segments to estimate the mean length of all conserved autosomal segments in the genome. This mean length was estimated to be 8.1 +/- 1.6 centimorgans. Evidence is presented suggesting that chromosomal rearrangements that determine the lengths of these segments are randomly distributed within the genome. The estimated mean length of conserved segments was used to predict the probability that certain loci, such as peptidase-3 and renin, are linked in man given that homologous loci are chi centimorgans apart in the mouse. The mean length of conserved segments was also used to estimate the number of chromosomal rearrangements that have disrupted linkage since divergence of man and mouse. This estimate was shown to be 178 +/- 39 rearrangements.
人类和小鼠中同源基因座的连锁关系被用于估计进化过程中保守的常染色体片段的平均长度。对83个以上同源基因座位置的比较揭示了13个保守片段。这13个片段最外侧标记之间的图谱距离在小鼠中是已知的，范围从1到24厘摩。已开发出方法，利用这些保守片段样本估计基因组中所有保守常染色体片段的平均长度。该平均长度估计为8.1±1.6厘摩。有证据表明，决定这些片段长度的染色体重排在基因组内是随机分布的。保守片段的估计平均长度被用于预测某些基因座（如肽酶-3和肾素）在人类中连锁的概率，前提是同源基因座在小鼠中相距χ厘摩。保守片段的平均长度还被用于估计自人类和小鼠分化以来破坏连锁的染色体重排数量。这一估计结果显示为178±39次重排。
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