Willard H F, Durfy S J, Mahtani M M, Dorkins H, Davies K E, Williams B R
Department of Medical Genetics, University of Toronto, Ontario, Canada.
Hum Genet. 1989 Feb;81(3):234-8. doi: 10.1007/BF00278995.
The gene encoding a tissue inhibitor of metallo-proteinases, TIMP, has previously been shown to be X-linked in both the human and mouse genomes. We have used a series of somatic cell hybrids segregating translocation and deletion X chromosomes to map the TIMP gene on the human X chromosome. In combination with previous data, the gene can be assigned to Xp11.23----Xp11.4. Genetic linkage analyses demonstrate that TIMP is linked to the more distal ornithine transcarbamylase (OTC) locus at a distance of about 22 centimorgans. The data are consistent with the conclusion that TIMP maps to a conserved synteny and linkage group on the proximal short arm of the human X chromosome and on the pericentric region of the mouse X chromosome, including loci for synapsin-1, a member of the raf oncogene family, OTC, and TIMP.
编码金属蛋白酶组织抑制剂（TIMP）的基因先前已表明在人类和小鼠基因组中均为X连锁。我们利用一系列分离易位和缺失X染色体的体细胞杂种，将TIMP基因定位到人类X染色体上。结合先前的数据，该基因可定位于Xp11.23----Xp11.4。遗传连锁分析表明，TIMP与更远端的鸟氨酸转氨甲酰酶（OTC）基因座连锁，距离约为22厘摩。这些数据与以下结论一致，即TIMP定位于人类X染色体近端短臂以及小鼠X染色体着丝粒周围区域的一个保守同线性和连锁群上，包括突触素-1（raf癌基因家族成员）、OTC和TIMP的基因座。
