Nutrition and Foods, Texas State University, San Marcos, Texas, USA.
Nutr Cancer. 2021;73(11-12):2232-2248. doi: 10.1080/01635581.2020.1856889. Epub 2020 Dec 8.
Obesity is associated with high-grade and advanced prostate cancer. While this association may be multi-factorial, studies suggest that obesity-induced inflammation may play a role in the progression of advanced prostate cancer. The microenvironment associated with obesity increases growth factors and pro-inflammatory cytokines which have been implicated mechanistically to promote invasion, metastasis, and androgen-independent growth. This review summarizes recent findings related to obesity-induced inflammation which may be the link to advanced prostate cancer. In addition, this review while introduce novel targets to mitigate prostate cancer metastasis to the bone. Specific emphasis will be placed on the role of the pro-inflammatory cytokines interleukin (IL)-6, tumor necrosis factor (TNF)α, and IL-1β.
肥胖与高级别和晚期前列腺癌有关。虽然这种关联可能是多因素的，但研究表明，肥胖引起的炎症可能在晚期前列腺癌的进展中发挥作用。与肥胖相关的微环境增加了生长因子和促炎细胞因子，这些因子在机制上被认为可促进侵袭、转移和雄激素非依赖性生长。这篇综述总结了与肥胖引起的炎症相关的最新发现，这可能是与晚期前列腺癌相关的联系。此外，本综述还介绍了减轻前列腺癌骨转移的新靶点。特别强调了促炎细胞因子白细胞介素（IL）-6、肿瘤坏死因子（TNF）α和 IL-1β的作用。
