• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Perspective: Is Cortical Hyperexcitability the Only Path to Generalized Absence Epilepsy?

作者信息

Huguenard John R

机构信息

Department of Neurology and Neurological Sciences, 10624Stanford University, Neurosciences Building, 290 Jane Stanford Way, Stanford, CA 94305, USA.

出版信息

Epilepsy Curr. 2020 Nov-Dec;20(6_suppl):59S-61S. doi: 10.1177/1535759720959325. Epub 2020 Oct 14.

DOI:10.1177/1535759720959325
PMID:33287573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7726732/
Abstract
摘要

相似文献

1
Perspective: Is Cortical Hyperexcitability the Only Path to Generalized Absence Epilepsy?观点：皮质兴奋性过高是全面性失神癫痫的唯一途径吗？
Epilepsy Curr. 2020 Nov-Dec;20(6_suppl):59S-61S. doi: 10.1177/1535759720959325. Epub 2020 Oct 14.
2
Patterns of cortical hyperexcitability in adolescent/adult-onset generalized epilepsies.青少年/成年起病的全面性癫痫的皮质过度兴奋性模式。
Epilepsia. 2013 May;54(5):871-8. doi: 10.1111/epi.12151. Epub 2013 Mar 29.
3
New vistas and views in the concept of generalized epilepsies.全身性癫痫概念的新视野与观点
Ideggyogy Sz. 2009 Nov 30;62(11-12):366-80.
4
Magnetic stimulation of the brain in generalized epilepsy: reversal of cortical hyperexcitability by anticonvulsants.全身性癫痫中脑的磁刺激：抗惊厥药对皮质过度兴奋的逆转作用。
Ann Neurol. 1993 Sep;34(3):351-5. doi: 10.1002/ana.410340308.
5
Generalized epilepsy with bilateral synchronous spike and wave discharge. New findings concerning its physiological mechanisms.双侧同步棘波和慢波放电的全身性癫痫。关于其生理机制的新发现。
Electroencephalogr Clin Neurophysiol Suppl. 1978(34):245-9.
6
Ictal high-frequency oscillations and hyperexcitability in refractory epilepsy.难治性癫痫中的发作期高频振荡与过度兴奋性
Clin Neurophysiol. 2015 Nov;126(11):2049-57. doi: 10.1016/j.clinph.2015.01.009. Epub 2015 Jan 24.
7
Video-EEG evidence of lateralized clinical features in primary generalized epilepsy with tonic-clonic seizures.伴有强直阵挛发作的原发性全身性癫痫中临床特征偏侧化的视频脑电图证据。
Epileptic Disord. 2003 Sep;5(3):149-56.
8
Consistent EEG focalities detected in subjects with primary generalized epilepsies monitored for two decades.在接受了二十年监测的原发性全身性癫痫患者中检测到一致的脑电图局灶性异常。
Epilepsia. 1997 Jul;38(7):797-812. doi: 10.1111/j.1528-1157.1997.tb01467.x.
9
Changes in cortical excitability differentiate generalized and focal epilepsy.皮质兴奋性的变化可区分全身性癫痫和局灶性癫痫。
Ann Neurol. 2007 Apr;61(4):324-31. doi: 10.1002/ana.21087.
10
Cortical excitability and recovery curve analysis in generalized epilepsy.全身性癫痫中的皮质兴奋性与恢复曲线分析
Neurology. 1999 Oct 12;53(6):1347-9. doi: 10.1212/wnl.53.6.1347.

引用本文的文献

1
Rhythmic Quakes Shock the Cortical Focus Theory.有节奏的震动冲击皮层聚焦理论。
Epilepsy Curr. 2025 Jun 8;25(3):187-189. doi: 10.1177/15357597251314673. eCollection 2025 May-Jun.
2
Absence seizures in lesion-related epilepsy.病灶相关性癫痫中的失神发作
Acta Epileptol. 2023 Sep 13;5(1):22. doi: 10.1186/s42494-023-00133-4.
3
From Physiology to Pathology of Cortico-Thalamo-Cortical Oscillations: Astroglia as a Target for Further Research.从皮质-丘脑-皮质振荡的生理学到病理学：星形胶质细胞作为进一步研究的靶点
Front Neurol. 2021 Jun 9;12:661408. doi: 10.3389/fneur.2021.661408. eCollection 2021.

本文引用的文献

1
Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures.消除 HCN2 起搏通道中的 cAMP 敏感性会引发全身性癫痫。
JCI Insight. 2019 May 2;4(9). doi: 10.1172/jci.insight.126418.
2
Ca 3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons.钙离子 3.2 驱动持续爆发式放电，这对网状丘脑神经元的失神发作传播至关重要。
Epilepsia. 2018 Apr;59(4):778-791. doi: 10.1111/epi.14018. Epub 2018 Feb 21.
3
Selective targeting of Scn8a prevents seizure development in a mouse model of mesial temporal lobe epilepsy.选择性靶向 Scn8a 可预防内侧颞叶癫痫小鼠模型中的癫痫发作。
Sci Rep. 2018 Jan 9;8(1):126. doi: 10.1038/s41598-017-17786-0.
4
Fully integrated silicon probes for high-density recording of neural activity.用于神经活动高密度记录的全集成硅探针。
Nature. 2017 Nov 8;551(7679):232-236. doi: 10.1038/nature24636.
5
Regulation of Thalamic and Cortical Network Synchrony by Scn8a.Scn8a对丘脑和皮层网络同步性的调节
Neuron. 2017 Mar 8;93(5):1165-1179.e6. doi: 10.1016/j.neuron.2017.01.031. Epub 2017 Feb 23.
6
Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.第六层皮质丘脑神经元中孤立的P/Q钙通道缺失会引发失神癫痫。
J Neurosci. 2016 Jan 13;36(2):405-18. doi: 10.1523/JNEUROSCI.2555-15.2016.
7
Beyond the hammer and the scalpel: selective circuit control for the epilepsies.超越锤子和手术刀：癫痫的选择性电路控制
Nat Neurosci. 2015 Mar;18(3):331-8. doi: 10.1038/nn.3943. Epub 2015 Feb 24.
8
Optogenetics and epilepsy: past, present and future.光遗传学与癫痫：过去、现在和未来。
Epilepsy Curr. 2015 Jan-Feb;15(1):34-8. doi: 10.5698/1535-7597-15.1.34.
9
Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome.人类遗传性失神癫痫综合征小鼠模型中丘脑内GABAA神经传递的改变
Neurobiol Dis. 2015 Jan;73:407-17. doi: 10.1016/j.nbd.2014.10.021. Epub 2014 Nov 4.
10
Transplantation of GABAergic Interneurons into the Neonatal Primary Visual Cortex Reduces Absence Seizures in Stargazer Mice.将γ-氨基丁酸能中间神经元移植到新生小鼠的初级视觉皮层可减少凝视小鼠的失神发作。
Cereb Cortex. 2015 Sep;25(9):2970-9. doi: 10.1093/cercor/bhu094. Epub 2014 May 8.