在被动双音听觉Oddball 范式中检测健康 4 周龄小猪的目标。
Target detection in healthy 4-week old piglets from a passive two-tone auditory oddball paradigm.
机构信息
Wallace H. Coulter Department of Biomedical Engineering, Emory University, 615 Michael St. Suite 655, Atlanta, GA, USA.
Emory University, Health Sciences Research Building 1760 Haygood Drive, Suite W242, 30322, Atlanta, Georgia.
出版信息
BMC Neurosci. 2020 Dec 7;21(1):52. doi: 10.1186/s12868-020-00601-4.
BACKGROUND
Passive auditory oddball tests are effort independent assessments that evaluate auditory processing and are suitable for paediatric patient groups. Our goal was to develop a two-tone auditory oddball test protocol and use this clinical assessment in an immature large animal model. Event-related potentials captured middle latency P1, N1, and P2 responses in 4-week old (N = 16, female) piglets using a custom piglet 32- electrode array on 3 non-consecutive days. The effect of target tone frequency (250 Hz and 4000 Hz) on middle latency responses were tested in a subset of animals.
RESULTS
Results show that infrequent target tone pulses elicit greater N1 amplitudes than frequent standard tone pulses. There was no effect of day. Electrodes covering the front of the head tend to elicit greater waveform responses. P2 amplitudes increased for higher frequency target tones (4000 Hz) than the regular 1000 Hz target tones (p < 0.05).
CONCLUSIONS
Two-tone auditory oddball tests produced consistent responses day-to-day. This clinical assessment was successful in the immature large animal model.
背景
被动听觉Oddball 测试是一种不依赖于努力的评估方法，可用于评估听觉处理能力，适用于儿科患者群体。我们的目标是开发一种双音听觉Oddball 测试方案，并将其应用于不成熟的大型动物模型中。通过使用定制的仔猪 32 电极阵列，在 3 个非连续的日子里，对 4 周龄（N=16，雌性）仔猪的事件相关电位进行了中间潜伏期 P1、N1 和 P2 反应的捕获。在一部分动物中测试了目标音频率（250 Hz 和 4000 Hz）对中间潜伏期反应的影响。
结果
结果表明，不频繁的目标音脉冲比频繁的标准音脉冲诱发更大的 N1 振幅。没有发现天数的影响。覆盖头部前方的电极往往会产生更大的波形反应。与常规的 1000 Hz 目标音相比，高频目标音（4000 Hz）的 P2 振幅增加（p < 0.05）。
结论
双音听觉 Oddball 测试每天都能产生一致的反应。这种临床评估在不成熟的大型动物模型中是成功的。
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