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年轻男性和老年男性桡骨远端骨折后的患者相关结局、骨折移位及骨密度

Patient-related outcome, fracture displacement and bone mineral density following distal radius fracture in young and older men.

作者信息

Egund Lisa, McGuigan Fiona E, Egund Niels, Besjakov Jack, Åkesson Kristina E

机构信息

Department of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Lund University, 205 02, Malmö, Sweden.

Department of Orthopedics, Skåne University Hospital, 205 02, Malmö, Sweden.

出版信息

BMC Musculoskelet Disord. 2020 Dec 7;21(1):816. doi: 10.1186/s12891-020-03843-9.

Abstract

BACKGROUND

Distal radius fractures can adversely affect wrist function; for men with this fracture, the role played by fracture severity, age and osteoporosis on fracture outcome has not been sufficiently studied.

OBJECTIVE

To describe patient-reported outcome and the association with bone integrity, fracture severity and future fracture risk among young and older men with distal radius fracture.

METHODS

This prospective study includes 133 men with acute distal radius fracture, mean age 54 (range 21-88), who were followed for 12 months. They were categorized as younger (< 65) and older (65+). Main outcome was DASH (Disability of the Arm, Shoulder and Hand) at 12 months; DASH > 15 was defined as poor outcome. Fractures were classified and radiographic displacement identified at initial presentation and follow-up. BMD was measured and FRAX 10-year probability of fracture calculated.

RESULTS

Disability was higher in older men (DASH 10 vs 2; p = 0.002); a clinically meaningful difference (ΔDASH = 10, p = 0.017) remained after adjustment for displacement, fracture classification and treatment method. Almost 50% of older men vs 14% in younger had poor outcome, p < 0.001. Bone mineral density did not independently predict outcome. Older men with a displaced fracture at initial presentation had greater disability (DASH, IQR 45, 14;73) and risk of fracture (FRAX 14, 8;21).

CONCLUSION

Men over the age of 65 with a distal radius fracture are more likely to have post-fracture disability regardless of radiographic appearance. Fracture displacement, indicating impaired bone strength, is also more common and associated with an increased risk of fracture within 10-years. Secondary fracture prevention should therefore be considered in men presenting with distal radius fracture.

摘要

背景

桡骨远端骨折会对腕关节功能产生不利影响;对于患有此类骨折的男性,骨折严重程度、年龄和骨质疏松症对骨折预后的作用尚未得到充分研究。

目的

描述桡骨远端骨折的年轻和老年男性患者报告的预后情况,以及与骨完整性、骨折严重程度和未来骨折风险的关联。

方法

这项前瞻性研究纳入了133例急性桡骨远端骨折男性患者,平均年龄54岁(范围21 - 88岁),随访12个月。他们被分为年轻组(<65岁)和老年组(65岁及以上)。主要结局指标是12个月时的上肢、肩部和手部功能障碍(DASH)评分;DASH评分>15被定义为预后不良。在初次就诊和随访时对骨折进行分类并确定影像学移位情况。测量骨密度并计算FRAX 10年骨折概率。

结果

老年男性的功能障碍程度更高(DASH评分10分对2分;p = 0.002);在对移位、骨折分类和治疗方法进行调整后,仍存在具有临床意义的差异(ΔDASH = 10,p = 0.017)。近50%的老年男性预后不良,而年轻组为14%,p < 0.001。骨密度并不能独立预测预后。初次就诊时出现移位骨折的老年男性功能障碍程度更高(DASH评分,四分位数间距45, 14;73)且骨折风险更高(FRAX评分14, 8;21)。

结论

65岁以上的桡骨远端骨折男性无论影像学表现如何,骨折后出现功能障碍的可能性更大。骨折移位表明骨强度受损,也更常见,且与10年内骨折风险增加相关。因此,对于桡骨远端骨折的男性应考虑进行二级骨折预防。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e74/7722451/12af790daf41/12891_2020_3843_Fig1_HTML.jpg

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