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革兰氏阴性杆菌对氨基糖苷类抗生素的敏感性

[Susceptibility of gram-negative bacilli to aminoglycosides].

作者信息

Willke A, Tural D

机构信息

A. U. Tip Fakültesi Oğretim Uyesi.

出版信息

Mikrobiyol Bul. 1987 Apr;21(2):98-102.

PMID:3328818
Abstract

In this study, the antibiotic sensitivity results of some gram-negative bacilli to aminoglycosides have been presented. 704 E. coli, 152 Klebsiella, 158 Proteus, 155 Pseudomonas strains were examined. These bacilli were isolated from the clinical samples at the bacteriology lab.in Ibni Sina Hospital, between January 1986-January 1987. The percents of E. coli strains susceptible to gentamicin, tobramycin, netilmicin and amikacin were 74%, 84%, 90%, 85% respectively. The sensitivity pattern of Proteus strains to the same antibiotic at the same order was 45%, 57%, 68, 84%. On the other hand 52%, 61%, 87%, 92% of Klebsiella strains and 32%, 53%, 86%, 81% of Pseudomonas strains have been found to be susceptible to gentamicin, tobramycin, netilmicin and amikacin respectively. According to these results, the resistance of gram-negative bacilli to aminoglycosides (including amikacin) is relatively high in our hospital, but amikacin or netilmicin should be preferred to others in which cases aminoglycoside therapy is considered.

摘要

在本研究中,呈现了一些革兰氏阴性杆菌对氨基糖苷类抗生素的药敏结果。检测了704株大肠杆菌、152株克雷伯菌、158株变形杆菌、155株假单胞菌。这些杆菌于1986年1月至1987年1月间从伊本·西那医院细菌学实验室的临床样本中分离得到。对庆大霉素、妥布霉素、奈替米星和阿米卡星敏感的大肠杆菌菌株百分比分别为74%、84%、90%、85%。变形杆菌菌株对相同抗生素的敏感模式按相同顺序分别为45%、57%、68%、84%。另一方面,已发现分别有52%、61%、87%、92%的克雷伯菌菌株和32%、53%、86%、81%的假单胞菌菌株对庆大霉素、妥布霉素、奈替米星和阿米卡星敏感。根据这些结果,我院革兰氏阴性杆菌对氨基糖苷类抗生素(包括阿米卡星)的耐药性相对较高,但在考虑使用氨基糖苷类抗生素治疗的情况下,应优先选择阿米卡星或奈替米星而非其他药物。

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